中国药物警戒 ›› 2025, Vol. 22 ›› Issue (10): 1162-1164.
DOI: 10.19803/j.1672-8629.20240830

• 安全与合理用药 • 上一篇    下一篇

注射用环磷酰胺致复发性多软骨炎患者急性药物性肝损伤1例分析

刘红1, 王钱2, 程永静2, 陈颖娟2,*   

  1. 1淄博市市立医院风湿免疫科,山东 淄博 255400;
    2北京医院风湿免疫科,国家老年医学中心,中国医学科学院老年医学研究院,北京 100730
  • 收稿日期:2024-10-30 出版日期:2025-10-15 发布日期:2025-10-20
  • 通讯作者: *陈颖娟,女,博士,主任医师,风湿免疫性疾病研究。E-mail: cyjnew@aliyun.com
  • 作者简介:刘红,女,硕士,主治医师,风湿免疫性疾病研究。
  • 基金资助:
    中央高水平医院临床科研业务费（BJ-2023-089）

One Case of Acute Drug-Induced Liver Injury Caused by Cyclophosphamide for Injection in a Patient with Relapsing Polychondritis

LIU Hong1, WANG Qian2, CHENG Yongjing2, CHEN Yingjuan2,*   

  1. 1Department of Rheumatology and Immunology, Zibo Municipal Hospital, Zibo Shandong 255400, China;
    2Department of Rheumatology and Immunity, Beijing Hospital, National Geriatric Medicine Center, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China
  • Received:2024-10-30 Online:2025-10-15 Published:2025-10-20

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摘要： 目的 探讨低剂量注射用环磷酰胺导致复发性多软骨炎患者急性药物性肝损伤的不良反应,为临床安全用药提供参考。方法 对 1例首次使用注射用环磷酰胺治疗复发性多软骨炎后出现急性肝损伤患者的临床资料进行分析,并结合相关文献回顾总结。结果 患者首次使用低剂量注射用环磷酰胺治疗后出现急性肝损伤,经及时停药并保肝治疗后转归良好。结论 首次应用环磷酰胺药品需警惕不良反应的个体差异;应尽早识别环磷酰胺药物性肝损伤危险因素、评估肝损伤类型及严重程度,并及时调整治疗。

关键词: 环磷酰胺, 注射用, 复发性多软骨炎, 急性药物性肝损伤, 肝功能, 药品不良反应

Abstract: Objective To analyze the acute drug-induced liver injury caused by low-dose cyclophosphamide for injection in a patient with relapsing polychondritis so as to provide a reference for clinicians. Methods The clinical data of a patient with relapsing polychondritis who developed acute drug-induced liver injury after the first low-dose intravenous application of cyclophosphamide was analyzed. The related literature was reviewed. Results The patient presented with acute liver injury after the first low-dose intravenous application of cyclophosphamide. After correlation analysis and multidisciplinary consultation, the patient was diagnosed with acute cyclophosphamide-induced liver injury. Cyclophosphamide was discontinued, and liver protection therapy was initiated, which led to a good prognosis. Conclusion Individual differences in adverse reactions deserve attention among patients who use cyclophosphamide for the first time. This drug should be used with caution. It is critical to identify the risk factors and assess the type and severity of cyclophosphamide induced liver injury so as to adjust the treatment in time.

Key words: Cyclophosphamide, Injection, Relapsing Polychondritis, Acute Drug-Induced Liver Injury, Liver Function, Adverse Drug Reactions

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