中国药物警戒 ›› 2018, Vol. 15 ›› Issue (5): 264-267.

• 基础与临床研究 • 上一篇    下一篇

维A酸在寻常型银屑病治疗中致甘油三酯升高的不良反应分析

秦海艳,陈丽娟,吴晓丽,朱虹,张,朱蕻潮   

  1. 南京医科大学附属淮安第一医院临床药学室，江苏淮安223300
  • 收稿日期:2017-10-24 修回日期:2018-06-21 出版日期:2018-05-20 发布日期:2018-06-21
  • 作者简介:秦海艳，女，本科，主管药师，临床药学。

Analysis of Adverse Reactions on the Elevated Triglyceride Levels Caused by Tretinoin Tablets in Treatment of Patients with Psoriasis Vulgaris

QIN Hai-yan,CHEN Li-juan,WU Xiao-li,ZHU Hong,ZHANG Yun,ZHU Hong-chao   

  1. Department of Clinical Pharmacy, The Affiliated Huaian NO.1 People's Hospital of NanJing Medical University, Jiangsu Huaian 223000, China
  • Received:2017-10-24 Revised:2018-06-21 Online:2018-05-20 Published:2018-06-21
  • Contact: 朱蕻潮,男,硕士,住院医师,心血管疾病的基础及影像学。E-mail：zhuhongchao366@126.com

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摘要： 目的 探讨维A酸在寻常型银屑病治疗中对甘油三酯的影响。方法 回顾性分析2014年5月至2016年4月在我院进行治疗的49例寻常型银屑病患者的临床资料，其中对照组24例，观察组25例，两组治疗前均测定甘油三酯水平，对照组给予抗炎和对症支持等常规治疗；观察组在对照组治疗基础上给予维A酸片口服，每次10 mg，每天3次；两组治疗后再次复查甘油三酯水平。每组治疗前后的甘油三酯水平比较采用配对样本t1检验，两组间的甘油三酯水平比较采用独立样本t2 检验。结果 对照组平均治疗（9.05±1.61）天，治疗前后甘油三酯水平分别为（1.09±0.64）mmol·L-1、（1.25±0.47）mmol·L-1，两者比较无统计学差异（t1=0.623，P >0.05）；观察组平均治疗（8.47±1.64）天，治疗前后甘油三酯水平分别为（1.27±0.45）mmol·L-1、（2.39±0.85）mmol·L-1，两者比较有统计学差异（t1=5.488，P <0.01），对照组及观察组治疗时间比较无统计学差异（t2=1.095，P >0.05），治疗前两组甘油三酯水平比较无统计学差异（t2=1.035，P >0.05），治疗后两组甘油三酯水平比较有统计学差异（t2=5.039，P <0.01）。结论 维A酸在寻常型银屑病治疗过程中能够在较短时间内升高甘油三酯水平，治疗后早期监测患者血脂变化情况可有效降低患者发生心脑血管疾病的风险。

关键词: 维A酸, 寻常型银屑病, 甘油三酯

Abstract: Objective To investigate the effect of tretinoin tablets in treatment of patients with psoriasis vulgaris on triglycerides.Methods Forty-nine patients with psoriasis vulgaris were enrolled from May 2014 to April 2016 in our hospital and randomly assigned to the control group(n=24) and observation group(n=25). The triglyceride levels of two groups were detected before treatment. The control group received anti-inflammatory or support therapy and the observation group received anti-inflammatory or support therapy plus taking tretinoin tablet 10 mg each time by three times a day. The triglyceride levels of two groups were detected after treatment. The paired t1 test were used for comparison the triglyceride levels before and after treatment, and independent sample t2 test were used for comparison between the triglyceride levels of two groups.Results The average time of therapy of control group was (9.05±1.61) days. The triglyceride levels of control group before and after treatment were (1.09±0.64) mmol·L-1, (1.25±0.47) mmol·L-1 respectively. The difference of them had no statistical significance (t1=0.623,P >0.623). The average time of therapy of observation group was(8.47±1.64) days. The triglyceride levels of observation group before and after treatment were (1.27±0.45) mmol·L-1, (2.39±0.85) mmol·L-1 respectively. The difference of them was statistically significant(t1=5.488, P <0.01). But the difference of the treatment time of two groups was not statistically significant (t2=1.095,P >0.05). The difference of the triglyceride levels of two groups before treatment also had no statistical difference (t2=1.035, P >1.035), but the triglyceride levels of two groups after treatment were statistical significant (t2=5.039, P <0.01).Conclusion Tretinoin tablets in treatment of patients with psoriasis vulgaris could raise the triglyceride levels in a short period of time. Early detecting the blood lipid changes in patients after treatment could effectively reduce the risk of cardiovascular disease in patients.

Key words: tretinoin tablets, psoriasis vulgaris, triglyceride

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