急性心肌梗死患者介入治疗后口服通心络胶囊对血清内皮细胞微粒及基质金属蛋白酶9水平的影响

中国药物警戒 ›› 2017, Vol. 14 ›› Issue (3): 142-144.

急性心肌梗死患者介入治疗后口服通心络胶囊对血清内皮细胞微粒及基质金属蛋白酶9水平的影响

刘学武, 张遐智^*, 张芳兰

洛南县中医医院,陕西洛南 726100

收稿日期:2017-04-20 修回日期:2017-04-20 出版日期:2017-03-20 发布日期:2017-04-20
通讯作者: 张遐智,男,本科,副主任医师,心脑血管内科临床。E-mail：xzqinsitong123@163.com
作者简介:刘学武,男,本科,副主任医师,心血管内科临床。

Effect of Oral Tongxinluo Capsule on Endothelial Microparticles and Matrix Metalloproteinase-9 in Serum of Patients with Acute Myocardial Infarction after Percutaneous Coronary Intervention

LIU Xue-wu, ZHANG Xia-zhi^*, ZHANG Fang-lan

Luonan County Hospital of Traditional Chinese Medicine, Shanxi Luonan 726100, China

Received:2017-04-20 Revised:2017-04-20 Online:2017-03-20 Published:2017-04-20

摘要/Abstract

摘要： 目的探讨急性心肌梗死（AMI）患者介入治疗后口服通心络胶囊对血清内皮细胞微粒（EMPs）和基质金属蛋白酶9（MMP-9）水平的影响。方法随机选取我院2013年8月至2016年1月收治的AMI患者144例,均接受PCI治疗,将患者通过随机数字表法分为观察组和对照组各72例,对照组介入术后常规治疗,观察组在此基础上口服通心络胶囊。对两组患者PCI手术前和术后7 天的EMPs和MMP-9水平进行检测。结果 PCI治疗后两组患者EMPs水平和MMP-9水平均比手术前有显著下降,差异具有统计学意义（P <0.05）,且观察组患者EMPs水平和MMP-9水平低于对照组,差异具有统计学意义（P <0.05）。两组患者PCI手术前和手术7 天后血清MMP-9和EMPs水平均呈正相关（P <0.05）。结论 AMI患者介入治疗后进行基础治疗联合通心络胶囊有利于降低外周血EMPs和MMP-9水平,维持血管内斑块稳定性,改善血管内皮细胞功能。

关键词: 急性心肌梗死, 冠状动脉介入术, 通心络胶囊, 内皮细胞微粒, 基质金属蛋白酶9

Abstract: Objective To investigate the effect of oral Tongxinluo capsule on endothelial microparticles (EMPs) and matrix metalloproteinase-9 (MMP-9) level in serum of patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI). Methods 144 cases of AMI patients in our hospital from August 2013 to January 2016 were randomly selected for the study and were treated with PCI. The patients were divided into the observation group and the control group by random number table. 72 patients in the control group received conventional treatment after PCI, while patients in the observation group were administered oral Tongxinluo capsule based on the conventional treatment. EMPs and MMP-9 levels of the two groups of patients before and 7 days after PCI were tested. Results EMPs and MMP-9 levels after PCI treatment of both the two groups of patients were lower than that before surgery, and the difference was statistically significant (P <0.05). EMPs and MMP-9 levels of the patients in the observation group were lower than that of the control group, and the difference was statistically significant (P <0.05). MMP-9 levels of the two groups of patients before and 7 days after PCI were both positively correlated with EMPs level (P <0.05). Conclusion Oral Tongxinluo capsule after PCI treatment for AMI patients helps to reduce EMPs and MMP-9 levels in peripheral blood, and contributes to maintain intravascular plaque stability and improve endothelial cell function.

Key words: acute myocardial infarction, percutaneous coronary intervention, Tongxinluo capsule, endothelial microparticle, matrix metalloproteinase-9

中图分类号:

R969

刘学武, 张遐智, 张芳兰. 急性心肌梗死患者介入治疗后口服通心络胶囊对血清内皮细胞微粒及基质金属蛋白酶9水平的影响[J]. 中国药物警戒, 2017, 14(3): 142-144.

LIU Xue-wu, ZHANG Xia-zhi, ZHANG Fang-lan. Effect of Oral Tongxinluo Capsule on Endothelial Microparticles and Matrix Metalloproteinase-9 in Serum of Patients with Acute Myocardial Infarction after Percutaneous Coronary Intervention[J]. Chinese Journal of Pharmacovigilance, 2017, 14(3): 142-144.

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