中国药物警戒 ›› 2010, Vol. 7 ›› Issue (7): 390-391.

• 基础研究 • 上一篇    下一篇

乳香没药挥发油入药的β-环糊精包合工艺及镇痛作用研究

谈英1, 雷永1, 周昆2, 毕波2, 陈金堂2   

  1. 1三九医药股份有限公司研发事业部,深圳 518029;
    2天津中医药大学中医药研究院,天津 300193
  • 收稿日期:2016-02-22 修回日期:2016-02-22 出版日期:2010-07-08 发布日期:2016-02-22
  • 作者简介:谈英,男,硕士,主治医师,药物安全性研究与新药研发。

Study on Preparation Process of β-cyclodextrin Inclusion with Volatile Oil of Olibanum and Myrrha and It's Analgesic Effect

TAN Ying1, LEI Yong1, ZHOU Kun2, BI Bo2, CHEN Jin-tang2   

  1. 1R&D Department of Sanjiu Medical&Pharmacutical CO.LTD Shenzhen 518029, China;
    2Institute of Traditional Chinese Medicine, Tianjin University of TCM Tianjin 300193, China
  • Received:2016-02-22 Revised:2016-02-22 Online:2010-07-08 Published:2016-02-22

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摘要： 目的 寻找乳香没药挥发油入药的β-环糊精（β-CD)包合工艺的可行性及最佳条件,并验证其镇痛效果。方法 提取乳香没药挥发油,比较不同比例下的包合物收得率和挥发油利用率,优选挥发油与β-CD包合物的的制备工艺,采用小鼠扭体法观察挥发油β-CD包合物与全粉镇痛效果。结果 挥发油：β-CD的最佳比例为1:10,此条件下包合物收得率大于97%、挥发油利用率大于92%;乳香没药生药粉和挥发油β-CD包合物均有抑制小鼠醋酸扭体的效果。结论 乳香没药挥发油可用β-CD包合的方式入药,而不影响其镇痛效果。

关键词: 乳香没药生药, 乳香没药挥发油β, -CD包合物, 镇痛作用

Abstract: Objective To explore the feasible preparation process of β-cyclodextrin inclusion with volatile oil of Olibanum and Myrrha and the best conditions, and verify its analgesic effect. Methods To extract volatile oil of Olibanum and Myrrha, compare the rate of yield and utilization whereas the different proportion of inclusion, thus to optimize the preparation process of β-CD inclusion compound. Mice writhing experiment was taken to explore the analgesic effect of crude powder and β-CD inclusion Compound respectively. Results The optimization ratio of volatile oil and β-CD inclusion was 1:10, and the yield rate of inclusion compound was greater than 97%, and the utilization rate was more than 92%. The crude powder and β-CD inclusion Compound respectively had an inhibitory effect on mice writhing induced by acetic acid. Conclusion The process of β-CD inclusion with volatile oil of Olibanum and Myrrha was possible without affecting its analgesic effect.

Key words: Olibanum+Myrrha crude powder, β-cyclodextrin inclusion with volatile oil of Olibanum and Myrrha, analgesic effect

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