中国药物警戒 ›› 2026, Vol. 23 ›› Issue (7): 753-756.
DOI: 10.19803/j.1672-8629.20260482

• 蒙药干预高血压性心肌肥厚的机制研究专栏 • 上一篇    下一篇

蒙药成方干预高血压性心脏损伤研究进展

郭玉婷1,2, 魏明慧3, 郭颖1,2, 董娜1,2, 薛明明1,*   

  1. 1内蒙古医科大学基础医学院,内蒙古 呼和浩特 010059;
    2内蒙古医科大学基础医学院医学神经生物学实验室,内蒙古 呼和浩特 010059;
    3内蒙古医科大学实验室与实验设备管理中心,内蒙古 呼和浩特 010059
  • 收稿日期:2026-06-10 出版日期:2026-07-15 发布日期:2026-07-16
  • 通讯作者: *薛明明,女,博士,教授,心血管生理学。E-mail: happybird-nmg@163.com
  • 作者简介:郭玉婷,女,博士,讲师,生物信息学与心血管生理学。
  • 基金资助:
    国家自然科学基金资助项目（82360095）; 内蒙古自治区高等学校创新团队发展计划项目（NMGIRT2420）; 内蒙古自然科学基金资助项目（2026ZD038）

Research progress in Mongolian medicine formulas for hypertensive cardiac injury

Guo Yuting1,2, Wei Minghui3, Guo Ying1,2, Dong Na1,2, Xue Mingming1,*   

  1. 1School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot Inner Mongolia 010059, China;
    2Laboratory of Medical Neurobiology, School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot Inner Mongolia 010059, China;
    3Center for Laboratory and Experimental Equipment Management, Inner Mongolia Medical University, Hohhot Inner Mongolia 010059, China
  • Received:2026-06-10 Online:2026-07-15 Published:2026-07-16

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摘要： 目的 系统梳理蒙药成方在高血压性心脏损伤中的研究现状,并结合相关中药研究,为蒙药作用机制阐释及后续药物研发提供参考。方法 查阅近年来高血压性心脏损伤、蒙药成方相关研究文献,围绕心肌肥厚、心室重构、心肌纤维化、炎症反应、氧化应激和代谢异常等病理环节,对代表性蒙药成方进行归纳分析。结果 高血压性心脏损伤涉及心肌细胞肥大、心脏重构、纤维化信号异常及代谢紊乱等多个过程。安神补心六味丸、肉豆蔻五味丸及四味土木香散等蒙药成方在心肌细胞保护、心脏重构、高血压性心肌肥厚及代谢调控方面具有一定研究价值,可能通过抗氧化、抗凋亡、调节钙稳态、保护线粒体功能及改善代谢网络等途径发挥作用。结论 蒙药成方干预高血压性心脏损伤具有一定研究潜力,未来需加强多组学联合功能验证和高质量临床研究。

关键词: 高血压, 高血压性心脏损伤, 安神补心六味丸, 肉豆蔻五味丸, 四味土木香散, 蒙药成方

Abstract: Objective To summarize the current research on Mongolian medicine formulas for hypertensive cardiac injury and provide insights into the mechanisms of Mongolian medicine and future development of drugs with reference to related studies on traditional Chinese medicine. Methods Recent literature on hypertensive cardiac injury and Mongolian medicine formulas was reviewed. Representative Mongolian medicine formulas and related TCM evidence were analyzed in general and key pathological processes in particular, including cardiac hypertrophy, ventricular remodeling, myocardial fibrosis, inflammation, oxidative stress, and metabolic abnormalities. Results Hypertensive cardiac injury involved multiple pathological processes, such as cardiomyocyte hypertrophy, cardiac remodeling, abnormal fibrotic signaling, and metabolic disorders. Current studies suggested that representative Mongolian medicine formulas, such as Anshen Buxin Liuwei pills, Nutmeg-5, and Siwei Tumuxiang powder, might be effective at cardiomyocyte protection, cardiac remodeling, hypertensive myocardial hypertrophy, and metabolic regulation. These formulas might exert cardioprotective effects through anti-oxidative, anti-apoptotic, calcium homeostasis-regulating, mitochondrial protective, and metabolic network-modulating mechanisms. In comparison, studies on TCM formulas and their active components against hypertensive cardiac injury were more full-fledged and might provide useful references for mechanistic studies of Mongolian medicine formulas. Conclusion Mongolian medicine formulas can be potentially used in interventions with hypertensive cardiac injury. However, current evidence remains limited by insufficient direct studies, unclear pharmacodynamic material bases, inadequate validation of core targets, and a lack of high-quality clinical data. More effort should be devoted to multi-omics-based functional validation and high-quality clinical research to shed light on their pharmacodynamic basis and mechanisms of action.

Key words: Hypertension, Hypertensive Cardiac Injury, Anshen Buxin Liuwei Pill, Nutmeg-5, Siwei Tumuxiang Powder, Mongolian Medicinal Formulas

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