中国药物警戒 ›› 2026, Vol. 23 ›› Issue (4): 470-472.
DOI: 10.19803/j.1672-8629.20250293

• 安全与合理用药 • 上一篇    下一篇

硫酸羟氯喹片致妊娠期急性泛发性发疹性脓疱病1例分析

和仲泉1, 潘燕2, 张国英2, 屠文莲3,*   

  1. 1丽江市玉龙县人民医院药剂科,云南 玉龙 674100;
    2大理大学药学院,云南 大理 671000;
    3云南省第一人民医院药学部,云南 昆明 650032
  • 收稿日期:2025-05-09 出版日期:2026-04-15 发布日期:2026-04-15
  • 通讯作者: *屠文莲,女,硕士,主任药师,临床药学。E-mail: tuwenlian18@aliyun.com
  • 作者简介:和仲泉,男,本科,药师,临床药学。

One Case of Acute Generalized Exanthematous Pustulosis Caused by Hydroxychloroquine Sulfate Tablets during Pregnancy

HE Zhongquan1, PAN Yan2, ZHANG Guoying2, TU Wenlian3,*   

  1. 1Department of Pharmacy, Yulong County People’ s Hospital, Lijiang Yunnan 674100, China;
    2School of Pharmacy, Dali University, Dali Yunnan 671000, China;
    3Department of Pharmacy, the First People’ s Hospital of Yunnan Province, Kunming Yunnan 650032, China;
  • Received:2025-05-09 Online:2026-04-15 Published:2026-04-15

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摘要： 目的 探讨1例妊娠期妇女使用硫酸羟氯喹片致急性泛发性发疹性脓疱病的病例,为临床合理用药提供参考。方法 梳理1例妊娠期使用硫酸羟氯喹片致急性泛发性发疹性脓疱病的病例,通过关联性评价和查阅国内外相关文献对此不良反应及发病机制进行分析,并提出防治措施。结果 判定硫酸羟氯喹片与急性泛发性发疹性脓疱病的关联性为很可能,立即停用硫酸羟氯喹片并给予糖皮质激素治疗后病情仍反复,加用对孕妇和胎儿较为安全的环孢素等药物治疗,相关症状及指标明显改善。结论 急性泛发性发疹性脓疱病为硫酸羟氯喹片罕见且严重的不良反应,给予甲泼尼龙联合环孢素软胶囊治疗后患者重症药疹症状明显改善,保障了孕妇和胎儿用药的安全性和有效性。

关键词: 硫酸羟氯喹片, 糖皮质激素, 环孢素软胶囊, 急性泛发性发疹性脓疱病, 妊娠期

Abstract: Objective To study one case of acute generalized exanthematous pustulosis caused by hydroxychloroquine sulfate tablets in a pregnant woman in order to provide a reference for rational clinical drug use. Methods One case of acute generalized exanthematous pustulosis caused by hydroxychloroquine sulfate tablets in a pregnant woman was analyzed. Based on association evaluation and related literature, the adverse reactions and its pathogenesis were investigated, and a treatment regimen was proposed. Results The association between hydroxychloroquine sulfate tablets and acute generalized exanthematous pustulosis was highly likely. After discontinuation of hydroxychloroquine sulfate tablets and start of corticosteroid therapy, the condition persisted. The clinical pharmacist recommended adding such medications as cyclosporine, which are relatively safe for pregnant women and fetuses, and the patient’s symptoms and indicators improved significantly. Conclusion Acute generalized exanthematous pustulosis is a rare and severe adverse reaction of hydroxychloroquine sulfate tablets. After treatment with methylprednisolone combined with cyclosporine soft capsules, the symptoms of severe drug eruption in patients can be significantly improved, ensuring the safety and effectiveness of drug use for pregnant women and fetuses.

Key words: Hydroxychloroquine Sulfate Tablets, Glucocorticoids, Ciclosporine Soft Capsules, Acute Generalized Exanthematous Pustulosis (AGEP), Pregnancy

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