围孕期抗癫痫药物使用指南解读与研究进展

doi:10.19803/j.1672-8629.20240436

中国药物警戒 ›› 2025, Vol. 22 ›› Issue (3): 357-360.
DOI: 10.19803/j.1672-8629.20240436

• 综述 • 上一篇

围孕期抗癫痫药物使用指南解读与研究进展

王然, 冯欣^*

首都医科大学附属北京妇产医院/北京妇幼保健院药事部,北京 100026

收稿日期:2024-06-26 出版日期:2025-03-15 发布日期:2025-03-17
通讯作者: ^*冯欣,女,硕士,主任药师,医院药学。E-mail: fengxin1115@ccmu.edu.cn
作者简介:王然,女,硕士,主管药师,围孕期用药安全。
基金资助:
北京市自然科学基金资助项目（7224354）;北京市医院管理中心青年人才培养“青苗”计划（QMS20221408）;首都卫生发展科研专项（首发2024-2-2115）;北京市属医院科研培育计划项目（PZ2022028）

Guidelines for the Use of Antiepileptic Drugs in the Periconception Period: Interpretations and Research Progress

WANG Ran, FENG Xin^*

Beijing Obstetrics and Gynecology Hospital, Capital Medical University/ Beijing Maternal and Child Health Care Hospital, Beijing 100026, China

Received:2024-06-26 Online:2025-03-15 Published:2025-03-17

摘要/Abstract

摘要： 目的探讨抗癫痫药物在围孕期对母体和胎儿的影响,为临床安全合理用药提供参考。方法针对各类抗癫痫药物与主要先天性畸形、不良围产结局、神经发育等相关性以及围孕期叶酸补充对母胎的影响进行论述及推荐,结合最新文献研究对指南进行解读。结果抗癫痫药物与先天性畸形、不良围产结局和神经发育存在相关性。围孕期一方面要使用药物有效控制癫痫发作,另一方面需要评估药物对胎儿的影响。结论合理使用抗癫痫药物并结合叶酸补充是保障癫痫患者母胎健康的关键,以提高产科安全用药水平。

关键词: 癫痫, 抗癫痫药物, 育龄癫痫人群, 叶酸, 致畸性, 围产结局, 指南解读

Abstract: Objective To investigate the impact of antiepileptic drugs on mothers and fetuses during the periconceptional period in order to provide a reference for obstetricians and pharmacists. Methods Research progress in the correlations between various antiepileptic drugs and major congenital malformations, adverse perinatal outcomes, and neurodevelopment, as well as the effects of folic acid supplementation during the periconceptional period on maternal and fetal health was summarized and recommendations were offered. Results Antiepileptic drugs were correlated with congenital malformations, adverse perinatal outcomes and neurodevelopment. During the periconceptional period, epileptic seizures needed to be brought under effective control via medications while the potential impact of these drugs on the fetus had to be assessed. Conclusion The rational use of antiepileptic drugs combined with folic acid supplementation is crucial to the health of mothers with epilepsy and fetuses.

Key words: Epilepsy, Antiseizure Medication, People with Epilepsy of Childbearing Potential, Folic Acid, Teratogenesis, Perinatal Outcomes, Guideline Interpretation

中图分类号:

R984

王然, 冯欣. 围孕期抗癫痫药物使用指南解读与研究进展[J]. 中国药物警戒, 2025, 22(3): 357-360.

WANG Ran, FENG Xin. Guidelines for the Use of Antiepileptic Drugs in the Periconception Period: Interpretations and Research Progress[J]. Chinese Journal of Pharmacovigilance, 2025, 22(3): 357-360.

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参考文献

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围孕期抗癫痫药物使用指南解读与研究进展

Guidelines for the Use of Antiepileptic Drugs in the Periconception Period: Interpretations and Research Progress

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