中国药物警戒 ›› 2022, Vol. 19 ›› Issue (8): 845-850.
DOI: 10.19803/j.1672-8629.2022.08.07

• 中成药适宜人群用药真实世界研究专栏 • 上一篇    下一篇

真实世界榄香烯乳状注射液用于老年人群的临床特征及联合用药分析

董晗硕1,2, 孙莉2, 赵晓晓1, 王连心1, 余小康3, 谢雁鸣1*   

  1. 1中国中医科学院中医临床基础医学研究所,北京 100700;
    2吉林省中医药科学院,吉林 长春 130000;
    3中国人民大学统计学院,北京 100872
  • 收稿日期:2022-01-05 出版日期:2022-08-15 发布日期:2022-08-15
  • 通讯作者: *谢雁鸣,女,研究员·博导,中药上市后评价和老年病防治。E-mail：ktzu2018@163.com
  • 作者简介:董晗硕,女,主治医师,中医药防治老年病。
  • 基金资助:
    国家自然科学基金资助项目（81973982）; 国家重点研发计划（2018YFC1707400）; 中国中医科学院科技创新工程项目（CI2021A00702）

Clinical characteristics and drug combination analysis of elemene injectable emulsion in the elderly in the real world

DONG Hanshuo1,2, SUN Li2, ZHAO Xiaoxiao1, WANG Lianxin1, YU Xiaokang3, XIE Yanming1*   

  1. 1Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China;
    2Jilin Academy of Chinese Medicine Sciences, Changchun Jilin 130000, China;
    3School of Statistics, Renmin University of China, Beijing 100872, China
  • Received:2022-01-05 Online:2022-08-15 Published:2022-08-15

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摘要： 目的 解析真实世界榄香烯乳状注射液治疗老年人群临床特征及联合用药情况,为该药的临床使用提供参考。方法 基于医院信息管理系统（HIS）大型集成数据仓库,提取2003年1月1日至2019年7月31日全国21家三甲医院的1 887例应用榄香烯乳状注射液治疗的老年患者电子医疗数据纳入分析。基于频数与构成比,对患者临床特征进行分析,并应用关联规则分析联合用药情况。结果 收集到至少使用过1次榄香烯乳状注射液治疗的1 887例老年患者的住院信息。立夏时节入院患者最多,男性多于女性,平均年龄为72.27岁;入院病情一般者占比最多,以肿瘤诊疗中心入院为主,平均住院天数为31.81 d;主要的西医诊断为肺恶性肿瘤、其他恶性肿瘤、高血压、肺部感染;给药途径最多为静脉滴注,绝大多数符合说明书给药途径;平均单次用药剂量为97.05 mL,平均用药天数为6.88 d;合并用药品种前5位按频数排序为维生素类、地塞米松、注射用胰岛素及其类似药物、胸腺肽、呋塞米。合并用药药理作用前5位按频数排序为抗肿瘤药、抗菌药、免疫促进药、矿物质补充剂、维生素类。结论 临床应用时需注意老年患者合并疾病种类较多,易出现多种药物联合使用的情况,且老年人安全用药知识水平较低,易造成药品不良反应/事件的发生,需提高医护人员在该方面的关注度。

关键词: 榄香烯乳状注射液, 真实世界研究, 老年, 临床特征, 联合用药

Abstract: Objective To analyze the clinical characteristics and drug combination of elemene injectable emulsion in the treatment of the elderly in the real world so as to provide reference for clinical use. Methods The clinical data on 1 887 senile patients treated with elemene injectable emulsion from 21 big hospitals in China between January 1, 2003 and July 31, 2019 was analyzed based on the Hospital Information System(HIS). The clinical characteristics of the patients were determined based on the frequency and composition ratio, and association rules were used to analyze combined medications. Results The clinical data on 1 887 elderly patients who had been treated with at least one elemene emulsion injection was collected. Most of the patients were admitted in the early summer. Male patients outnumbered female ones and their age averaged 72.27. Patients with mild symptoms accounted for the largest proportion and were treated in the Center of Oncology. The average length of hospital stay was 31.81 days. Malignant tumors, hypertension and lung infections were prevalent among these patients. Intravenous infusion was the dominating administration route in line with the instructions. The average single dosage was 97.05 mL, and the average days of medication were 6.88. The top five drug combinations were listed in order of frequency: vitamins, dexamethasone, insulin for injection and similar drugs, thymosin, and furosemide. The top five types of combined drugs were ranked in order of frequency: anti-tumor drugs, immunostimulants, antibacterial drugs, mineral supplements and vitamins. Conclusion In clinical practice, it is worthy of note that many diseases are associated with elderly patients, and the combination of multiple drugs is common. In addition, the elderly tend to have a poor knowledge of safe drug use, which is likely to cause adverse drug reactions/events.

Key words: elemene injectable emulsion, real-world study, elderly, clinical features, drug combination

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