轮状病毒疫苗和肠套叠关联性的研究进展

中国药物警戒 ›› 2015, Vol. 12 ›› Issue (4): 241-244.

轮状病毒疫苗和肠套叠关联性的研究进展

王亚丽,董铎

国家食品药品监督管理总局药品评价中心，北京 100045

收稿日期:2014-11-05 出版日期:2015-04-08 发布日期:2015-07-27
作者简介:王亚丽，女，博士，副主任药师，药品不良反应监测与评价。

Researches about the Relationship between Rotavirus Vaccine and Intussusception

WANG Ya-li,DONG Duo

Center for Drug Reevaluation, CFDA，Beijing 100045, China

Received:2014-11-05 Online:2015-04-08 Published:2015-07-27

摘要/Abstract

摘要： 轮状病毒感染是引起儿童腹泻的主要原因。在发达国家，由轮状病毒感染导致的急诊和住院造成了巨大的经济负担，在发展中国家则是导致儿童死亡的主要原因。使用疫苗是预防轮状病毒感染的有效手段。1999年，第一代轮状病毒疫苗RotaShield由于怀疑能增加接种儿童罹患肠套叠风险而撤市。2006年，第二代轮状病毒疫苗RotaTeq和Rotarix先后上市，第二代轮状病毒疫苗与肠套叠的关联性仍是当前关注的热点。目前各国尚无针对轮状病毒疫苗接种规程的新的举措。通过综述了有关轮状病毒疫苗和肠套叠开展的关联性研究,以期为轮状病毒疫苗的安全使用提供参考。

关键词: 轮状病毒, 轮状病毒疫苗, 肠套叠

Abstract: Rotavirus is the main cause of diarrheal illness among children. In developed countries, it's a huge financial burden of emergency and hospitalization due to rotavirus infection. In developing countries, it's the main reason to children death. Vaccination is one of the effective Methods to prevent the disease. The first vaccine, RotaShield, was withdrawn from the market in 1999 because it was suspected to increase the risk of intussusception in recipients. In 2006, the new vaccine, RotaTeq and Rotarix, were introduced to the market. The relationship between rotavirus vaccine and intussusception is still the hot topic. There are still no changes of immunization program about rotavirus vaccine in the world.In the paper, the researches about rotavirus vaccine and intussusception are summarized.

Key words: rotavirus, rotavirus vaccine, intussusception

中图分类号:

王亚丽,董铎. 轮状病毒疫苗和肠套叠关联性的研究进展[J]. 中国药物警戒, 2015, 12(4): 241-244.

WANG Ya-li,DONG Duo. Researches about the Relationship between Rotavirus Vaccine and Intussusception[J]. Chinese Journal of Pharmacovigilance, 2015, 12(4): 241-244.

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