孕期暴露因素与新生儿血管瘤发生的关联性研究

中国药物警戒 ›› 2012, Vol. 9 ›› Issue (3): 140-143.

孕期暴露因素与新生儿血管瘤发生的关联性研究

王琳¹，米双利²，陈杰¹，刘芳¹，李迎春¹，郭彩虹¹，张勇¹，范钦颖¹

1 卫生部中日友好医院预防保健科，北京 100029；
2 中科院北京基因组研究所，重大疾病基因组与个体化医疗实验室，北京 100029

收稿日期:2011-12-21 出版日期:2012-03-10 发布日期:2015-08-10
作者简介:王琳，女，副主任医师，新生儿出生缺陷与遗传代谢病。

Study on the Maternal Exposure during Pregnancy and Infantile Hemangioma

WANG Lin¹, MI Shuang-li², CHEN Jie¹, LIU Fang¹, LI Ying-chun¹, GUO Cai-hong¹, ZHANG Yong¹, FANG Qin-ying¹

1 Prevention and Health care Section, China-Japan Friendship Hospital, Beijing 100029, China;
2 Laboratory of Disease Genomics and Individualized Medicine, Beijng Institute of Genomics, Chinese Academy of Sciences, Beijing 100029, China

Received:2011-12-21 Online:2012-03-10 Published:2015-08-10

摘要/Abstract

摘要： 目的探讨新生儿血管瘤发生的高危因素，分析孕期暴露因素与新生儿血管瘤发生的关联。方法对我院所辖大型社区2010年1月至2011年6月出生新生儿的母亲进行回顾性调查研究，对此阶段出生的新生儿母亲进行问卷调查，包括孕妇基本情况、孕期疾病和用药、服用多种维生素;对新生儿血管瘤患儿母亲与正常新生儿母亲的上述因素进行比较，采用logistic回归分析筛选与血管瘤发生相关的因素。结果共获得有效问卷953例，发现34例血管瘤病例;对这34例患儿母亲的孕期暴露因素与正常新生儿母亲的比较发现，母亲年龄≥35岁、儿童性别、黄体酮和过量服用多种维生素是与新生儿血管瘤发生明显相关的孕期暴露因素（Wald χ2 分别为4.932、5.592、5.065、7.585，P值分别为0.026、0.018、0.024、0.006）;父亲年龄、上感、发热和抗感冒中药与血管瘤的发生无明显关联（P >0.05）。结论除了高龄孕产和儿童性别外，孕期使用黄体酮和过量服用维生素可能是新生儿血管瘤发生的高危因素。

关键词: 新生儿血管瘤, 高危因素, 黄体酮, 过量服用维生素

Abstract: Objective To explore the possible factors for infantile hemangiomas(IHs) with a focus on maternal exposure during pregnancy. MethodsA retrospective analysis was carried out on the neonatal mothers who gave birth to from January 1, 2010 to June 30, 2011 when they presented to the postpartum. All of them were invited to complete a questionnaire including maternal life history, diseases, drug administration and supplementation of multivitamin during pregnancy. Comparison of the maternal factors between the suffered and normal neonate group was conducted by using logistic regression analysis. ResultsDetail information of a total of 953 mothers was collected and 34 of infants were found developing IHs. The results revealed that the advanced maternal age, baby gender, progesterone and over-supplementation of multivitamin(Wald χ2 were 4.932、5.592、5.065、7.585 respectively, P value 0.026、0.018、0.024、0.006 respectively) were the potential factors for developing IHs while no significant difference was found in the paternal age, fever, upper respiratory infection and the administration of Traditional Chinese Medicine(All P value >0.05). ConclusionBesides the advanced maternal age and baby gender as reported in foreign study, our study suggests that progesterone and over-supplementation of multivitamin may be possible factors for developing IHs.

Key words: infantile hemangiomas, risk factor, progesterone, over-supplementation of multivitamin

王琳，米双利，陈杰，刘芳，李迎春，郭彩虹，张勇，范钦颖. 孕期暴露因素与新生儿血管瘤发生的关联性研究[J]. 中国药物警戒, 2012, 9(3): 140-143.

WANG Lin, MI Shuang-li, CHEN Jie, LIU Fang, LI Ying-chun, GUO Cai-hong, ZHANG Yong, FANG Qin-ying. Study on the Maternal Exposure during Pregnancy and Infantile Hemangioma[J]. Chinese Journal of Pharmacovigilance, 2012, 9(3): 140-143.

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