中国药物警戒 ›› 2012, Vol. 9 ›› Issue (2): 117-118.

• 药品不良反应监测 • 上一篇    下一篇

万古霉素致白细胞减少症38例回顾性分析

刘丽英1，李勇2，古淑仪3   

  1. 1 江西省于都县人民医院，江西 于都 342300；
    2 北京军区总医院，北京 100700；
    3 广州市红十字会医院，广东 广州 510220
  • 收稿日期:2011-09-26 出版日期:2012-02-10 发布日期:2015-08-10
  • 作者简介:刘丽英，女，主管药师，临床药学。

Retrospective Analysis of 38 Granulocytopenia Cases Induced by Vancomycin

LIU Li-ying1, LI Yong2, GU Shu-yi3   

  1. 1 The people's Hospital of Yudu County, Jiangxi Yudu 342300, China;
    2 General Hospital of Beijing Military Region, Beijing 100700, China;
    3 Guangzhou Red Cross Hospital, Guangdong Guangzhou 510220, China
  • Received:2011-09-26 Online:2012-02-10 Published:2015-08-10

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摘要： 目的研究万古霉素致白细胞减少的临床特点。方法收集2006年1月~2011年6月我院发生的38例病例患者的临床资料，并对其年龄、性别、用药情况、出现白细胞减少症的临床表现及预后进行分析。结果38例患者中男26例（68.42%），女12例（31.58%）。年龄16~71岁，平均年龄39.66±9.86岁。使用万古霉素的疗程7~27天，白细胞值最低的为0.49×109/L，所有病例均在出现白细胞减少时停用万古霉素，有6例给予升白细胞药，有32例未做其他特殊处理，2~7天后38例患者白细胞及中性粒细胞均得到恢复。结论万古霉素引起的白细胞减少症是可逆的，但在此期间发生合并感染的风险增加，故临床仍要引起高度重视。

关键词: 万古霉素, 不良反应, 白细胞减少

Abstract: Objective To study the clinical traits of granulocytopenia induced by vancomycin. MethodsClinical information of 38 granulocytopenia cases at our hospital from jaunary to june in 2006 was collected, and age, gender, medication, clinical manifestation of granulocytopenia and prognosis were analyzed. Results26 patients (68.42%) were male in 38 cases and 12 were female(31.58%). The average age was 39.66±9.86 years old. The course of treatment by vancomycin was 7~27 days. The minimum of leucocytes count was 0.49×109/L. Vancomycin withdrawal was adopted in all patients, among whom 6 patients received drugs to elevate leucocytes and 32 patients not received any special treatments. All patients' leucocytes and neutrophils returned to normal ranges after 2~7 days. ConclusionGranulocytopenia induced by vancomycin is reversible, whereas the risk of concurrent infection is increased, which should be paid much attention to.

Key words: Vancomycin, adverse reaction, granulocytopenia