中国药物警戒 ›› 2012, Vol. 9 ›› Issue (1): 38-42.

• 综述 • 上一篇    下一篇

樟脑药理毒理研究回顾及安全性研究展望

丁元刚，马红梅*，张伯礼   

  1. 天津中医药大学，天津300193
  • 收稿日期:2011-09-22 出版日期:2012-01-10 发布日期:2015-08-10
  • 通讯作者: 马红梅,女,博士,研究员,博士生导师,中药药理毒理与安全性评价。E-mail：mahongmeihao@126.com
  • 作者简介:丁元刚，男，硕士研究生，中药代谢和毒理研究。

Research on Pharmacology, Toxicology and Safety of Camphor: Review and Prospect

DING Yuan-gang, MA Hong-mei, ZHANG Bo-li   

  1. Tianjin University of Traditional Chinese Medicine Tianjin 300193, China
  • Received:2011-09-22 Online:2012-01-10 Published:2015-08-10

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摘要： 樟脑有兴奋、强心、消炎、镇痛、抗菌、止咳、促渗、杀螨等药理作用，并与其他药物间相互作用，是世界上最早被使用的天然有机化学成分之一。樟脑应用广泛，又具有较强毒性，表现在对卵巢、睾丸、神经、肝脏、心脏、胎儿、孕妇的明显毒性，对肾脏泌尿系统的潜在毒性和较小遗传毒性。近年来，冰片与樟脑体内转化及相互关系研究课题引人关注，我们认为有必要了解樟脑药理毒理及安全性方面的进展，为深入研究冰片与樟脑体内转化及相互关系提供参考。

关键词: 樟脑, 冰片, 药理学, 毒理学, 安全性研究

Abstract: Camphor have many pharmacological effects, such as excitement, cardiac, anti -inflammatory, analgesic,antibacterial, cough, penetration, reduce mitochondrial respiration, regulating liver enzyme, mites,and Interactions with other drugs, is one of the world's first natural organic ingredients be used. Camphor is widely used, but also has a strong toxicity, manifested in the ovary, testes, nerves, liver, heart, fetus, pregnant women, the apparent toxicity to the kidneys and urinary system less genotoxic potential toxicity. In recent years, research subject of the transformation and the relationship borneol and camphor in body fetching attention, we consider it necessary to understand the pharmacology and toxicology and safety of camphor progress, provide a reference for in-depth study of the relationship between body transformation of borneol and camphor.

Key words: camphor, borneol, pharmacology, toxicology, safety study