盐酸胺碘酮注射液致急性肝衰竭1例分析

doi:10.19803/j.1672-8629.20250359

中国药物警戒 ›› 2026, Vol. 23 ›› Issue (2): 197-199.
DOI: 10.19803/j.1672-8629.20250359

盐酸胺碘酮注射液致急性肝衰竭1例分析

江文豪¹, 徐红冰², 张小刚³, 吴江平^2,*

¹上海交通大学附属第一人民医院急诊危重病科，上海 200080;
²上海交通大学附属第一人民医院临床药学科，上海 200080;
³同济大学附属东方医院药学部，上海 200120

收稿日期:2025-06-05 出版日期:2026-02-15 发布日期:2026-02-13
通讯作者: ^*吴江平，男，本科，药师，临床药学。E-mail: wujiangping@whu.edu.cn
作者简介:江文豪，男，硕士，医师，急危重症。

One Case of Acute Liver Failure Caused by Amiodarone Injection

JIANG Wenhao¹, XU Hongbing², ZHANG Xiaogang³, WU Jiangping^2,*

¹Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China;
²Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China;
³Department of Pharmacy, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China

Received:2025-06-05 Online:2026-02-15 Published:2026-02-13

摘要/Abstract

摘要： 目的探讨盐酸胺碘酮（以下简称“胺碘酮”）引起急性肝衰竭的原因及临床特征，为临床安全用药提供参考。方法分析1例使用胺碘酮注射液后出现急性肝衰竭的病例，结合文献梳理胺碘酮引起急性肝衰竭的关联性、原因及临床特征。结果经关联性评价，本例患者的急性肝衰竭与胺碘酮很可能相关，停药后予保肝治疗，肝酶指标较前好转，但因病情加重最终放弃治疗。结论胺碘酮引起急性肝衰竭较罕见且后果严重，临床应警惕药品不良反应，做到合理规范用药，早期识别并及时干预，从而改善患者预后。

关键词: 胺碘酮, 药物性肝损伤, 肝衰竭, 药学监护, 药品不良反应

Abstract: Objective To investigate the causes and clinical characteristics of acute liver failure induced by amiodarone in order to provide a reference for safe clinical medications. Methods One case of acute liver failure following administration of amiodarone hydrochloride injection was analyzed while the association, causes, and clinical features regarding acute liver failure caused by this drug were explored based on related literature. Results Correlation analysis showed that acute liver failure was strongly associated with amiodarone in this patient. Liver enzyme levels improved after discontinuing the medication and initiating therapy, but treatment was ultimately discontinued due to worsening condition. Conclusion Despite the low incidence of acute liver failure induced by amiodarone, the consequent adverse reactions can be severe. Clinicians should be alert to adverse drug reactions, adhere to rational and standardized prescriptions, and ensure early identification and interventions to improve the prognosis of patients.

Key words: Amiodarone, Drug-induced Liver Injury, Liver Failure, Pharmaceutical Care, Adverse Drug Reactions

中图分类号:

R972

江文豪, 徐红冰, 张小刚, 吴江平. 盐酸胺碘酮注射液致急性肝衰竭1例分析[J]. 中国药物警戒, 2026, 23(2): 197-199.

JIANG Wenhao, XU Hongbing, ZHANG Xiaogang, WU Jiangping. One Case of Acute Liver Failure Caused by Amiodarone Injection[J]. Chinese Journal of Pharmacovigilance, 2026, 23(2): 197-199.

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盐酸胺碘酮注射液致急性肝衰竭1例分析

One Case of Acute Liver Failure Caused by Amiodarone Injection

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