中国药物警戒 ›› 2012, Vol. 9 ›› Issue (9): 555-557.

• 药械质量与工艺研究 • 上一篇    下一篇

正交实验法优选前列安浓缩丸的制备工艺

严霞 ,肖晏婴 , 赵映波 ,尉迟白甫   

  1. 湖北省中医药大学附属襄阳市中医医院, 湖北襄阳441000
  • 收稿日期:2012-03-01 出版日期:2012-09-10 发布日期:2015-08-07
  • 作者简介:严霞,女,本科,主管中药师,中药制剂。

Optimization of Preparation Technology for Qianliean Concentrated Pill by Orthogonal Test

YAN Xia ,XIAO Yan-ying, ZHAO Ying-bo ,YUCHI Bai-fu   

  1. Hubei Traditional Chinese Medicine University Affiliated Hospital of Xiangyang Traditional Chinese Medicine, Hubei Xiangyang 441000, China
  • Received:2012-03-01 Online:2012-09-10 Published:2015-08-07

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摘要： 目的 优选前列安浓缩丸的最佳制备工艺,以控制其溶散时限在质量标准范围内。方法 在固定干燥温度、干燥时间的条件下,以前列安丸溶散时限为指标进行正交分析。结果 优选的前列安浓缩丸的最佳制备工艺为A2B1C2,即采用方案乙（郁金、丹参、石菖蒲、黄柏制粉,余药提取浸膏）,药粉细度为80目,清膏比重为1.30。结论 正交实验法优选出的提取工艺使前列安浓缩丸的综合质量得到最大提高,此时药丸水分含量控制在6.0~7.5%,溶散时限完全符合规定。

关键词: 正交实验法, 前列安丸, 制备工艺, 溶散时限

Abstract: Objective To optimize the best preparation technology of Qianliean concentrated pill and control its resolving time in quality standard range. Methods In the condition of the fixed drying temperature and drying time, orthogonal test was performed with the dissolving time as index. Results The best preparation technology of Qianliean concentrated pill was A2B1C2, thus using the plan B, in which Curcumae Radix, Salviae Miltiorrhizae Radix et Rhizoma, Acori Tatarinowii Rhizoma, and Phellodendri Chinensis Cortex were made powder, and the others remained were extracted. The powder fineness was 80 mesh, and paste proportion was 1.30. Conclusion The comprehensive quality of Qianliean concentrated pill was greatly improved under the optimizated extraction technology by orthogonal test. In this case, the moisture content of pills was controlled in the range of 6~7.5%, and resolving time was in full compliance with the provision.

Key words: orthogonal test, Qianliean concentrated pill, preparation technology, dissolving time