真实世界喜炎平注射液治疗病毒性肠道感染数据挖掘及分析

doi:10.19803/j.1672-8629.2022.02.01

中国药物警戒 ›› 2022, Vol. 19 ›› Issue (2): 117-120.
DOI: 10.19803/j.1672-8629.2022.02.01

• 真实世界中成药用药方案研究专栏 • 上一篇下一篇

真实世界喜炎平注射液治疗病毒性肠道感染数据挖掘及分析

汲泓^1,2, 王志飞^1#, 谢雁鸣^1,*, 李利寻¹, 魏瑞丽¹, 王淇³

¹中国中医科学院中医临床基础医学研究所,北京 100700;
²辽宁中医药大学附属医院,辽宁沈阳 110032;
³中国人民大学统计学院,北京 100872

收稿日期:2021-03-05 出版日期:2022-02-15 发布日期:2022-02-15
通讯作者: ^*谢雁鸣,女,研究员·博导,中医临床评价方法。E-mail：ktzu2018@163.com,#为共同通信作者。
作者简介:汲泓,女,主任医师·硕导,中西医结合风湿免疫。
基金资助:
国家重点研发计划（2018YFC1707410）

Data mining and network analysis of Xiyanping injection in the treatment of viral intestinal infection based on the real world

JI Hong^1,2, WANG Zhifei^1#, XIE Yanming^1,*, LI Lixun¹, WEI Ruili¹, WANG Qi³

¹Institute of Clinical Basic Medicine of Traditional Chinese Medicine, Chinese Academy of Traditional Chinese Medicine, Beijing 100700, China;
²Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang Liaoning 110032, China;
³School of Statistics, Renmin University of China, Beijing 100872, China

Received:2021-03-05 Online:2022-02-15 Published:2022-02-15

摘要/Abstract

摘要： 目的对喜炎平注射液治疗病毒性肠道感染的用药特征进行分析,以指导临床合理用药。方法基于中国中医科学院中医临床基础医学研究所构建的医院信息管理系统（HIS）数据库,对29家医院2006年12月1日至2016年6月30日间1 814例使用喜炎平注射液治疗的肠道感染患者进行临床特征和联合用药关联规则分析,采用Tabu搜索算法进行数据处理。结果喜炎平注射液联用西药中用药次数最多的是口服补液盐、复合维生素、西咪替丁类药和抗生素类药;联用中药中用药次数最多的是清热剂、固涩剂和清热解毒剂。结论在病毒性肠道感染治疗中,较推荐的治疗方案是应用喜炎平注射液联合补液、中药固涩剂,达到抗病毒、止泻、调整胃肠道环境。

关键词: 真实世界, 喜炎平注射液, 病毒性肠道感染, 复杂网络

Abstract: Objective To analyze the way in which Xiyanping injection is used in the treatment of viral intestinal infections so as to guide clinical rational medication. Methods Based on the hospital information management system (HIS) database constructed by the Institute of Clinical Basic Medicine of Chinese Academy of Traditional Chinese Medicine, the clinical data on 1 814 patients with intestinal infections treated with Xiyanping injection in 29 hospitals between December 1, 2006 and June 30, 2016 was analyzed; and the patterns of combined medications were studied. The data was processed with the Tabu search algorithm. Results The most frequently used western medicine was oral rehydration salt, compound vitamin, cimetidine and antibiotics. The most frequently used traditional Chinese medicine was antipyretic, astringent and antipyretic antidote. Conclusion In the treatment of viral intestinal infections, Xiyanping injection is often combined with vitamins, oral rehydration salt or with antipyretic antidotes and astringents to combat viruses, cure diarrhea, adjust the gastrointestinal environment and provide symptomatic treatment.

Key words: real world, Xiyanping injection, viral intestinal infection, complex network

中图分类号:

R932R975

汲泓, 王志飞, 谢雁鸣, 李利寻, 魏瑞丽, 王淇. 真实世界喜炎平注射液治疗病毒性肠道感染数据挖掘及分析[J]. 中国药物警戒, 2022, 19(2): 117-120.

JI Hong, WANG Zhifei, XIE Yanming, LI Lixun, WEI Ruili, WANG Qi. Data mining and network analysis of Xiyanping injection in the treatment of viral intestinal infection based on the real world[J]. Chinese Journal of Pharmacovigilance, 2022, 19(2): 117-120.

导出引用管理器 EndNote|Ris|BibTeX

链接本文: https://zgywjj.magtechjournal.com/CN/10.19803/j.1672-8629.2022.02.01

https://zgywjj.magtechjournal.com/CN/Y2022/V19/I2/117

参考文献

[1] KANG P.Xi Yanping's therapeutic effect and safety analysis on rotav-irus enteritis in children[J]. China Modern Drug Application(中国现代药物应用), 2020, 14(2): 152-153.
[2] YUAN X.Analysis of pathogenic factors of 200 cases of infantile diarrhea and its clinical treatment significance[J]. Smart Healthcare(智慧健康), 2018, 16: 14.
[3] LI SD.Progress in the treatment of children’s diarrhea[J]. Forum on Primary Medicine(基层医学论坛), 2016, 20(6): 817-819.
[4] ZHANG JZ.Progress in drug treatment of viral enteritis in children[J]. Journal of Appropriate Clinical Medication(临床合理用药), 2019, 12(2): 2.
[5] WANG ZF, XIE YM.Xiyanping injection HIS clinical dose application analysis based on the real world[J]. Chinese Journal of Chinese Materia Medical(中国中药杂志), 2012, 37(18): 2727-2729.
[6] ZHOU W, LUO YC.Observation on the curative effect of Xiyanping in the treatment of 58 cases of infantile rotavirus diarrhea with myocardial damage[J]. Zhejiang Journal of Traditional Chinese Medicine(浙江中医杂志),2013, 48(8): 8.
[7] WANG SH.Clinical literature research on the treatment of enteritis by Gegen Qinlian Decoction based on main databases[D]. China Academy of Chinese Medical Sciences, 2020.
[8] CAI S, ZHU QX.Research progress in rotavirus infection[J]. Chinese Clinical Research(中国临床研究), 2019, 32(8): 1132-1134.
[9] LU YB.48 cases of infantile autumn diarrhea treated with montmor-illonite powder and shenlingbaizhu granule[J]. JCM(社区医学杂志), 2012, 10(2): 3.
[10] LIU Q.The clinical effect of moxibustion combined with montmorillonite powder and bifidobacterium triple viable bacteria powder in the treatment of rotavirus enteritis in children[J]. China Contemporary Medicine(中国当代医药), 2019, 26(2): 98-100.
[11] WANG LX, YANG W, XIE YM, et al.4023 cases of real-world
clinical application and safety analysis of Xiyanping injection patients[J]. Journal of Traditional Chinese Medicine(中医杂志), 2014, 55(7): 571-575.
[12] DU LJ, XIE YM, WANG ZF, et al.Analysis of the influence of Xiyanping injection on renal function in the real world based on propensity scoring method[J]. Beijing Traditional Chinese Medicine(北京中医药), 2016, 35(3):205-206.

[1]	李栋, 赵燕. 国家人工关节置换登记系统在医疗器械上市后监测中的作用与思考[J]. 中国药物警戒, 2025, 22(6): 640-644.
[2]	解子乐, 王成祥, 胡彦鹏, 李磊, 崔鹤蓉. 中药治疗感染后咳嗽的临床用药规律与安全性分析[J]. 中国药物警戒, 2025, 22(5): 507-512.
[3]	王栓, 黄灿, 齐腊梅. 基于真实世界数据研究阿帕替尼致高血压预测模型的建立与评价[J]. 中国药物警戒, 2025, 22(4): 429-435.
[4]	聂晓璐, 赵厚宇, 霍东辉, 阎爱侠, 孙凤, 彭晓霞, 倪鑫, 詹思延. 基于真实世界数据与定量构效关系的儿童药源性免疫性血小板减少症研究[J]. 中国药物警戒, 2025, 22(1): 16-22.
[5]	孙一鑫, 聂晓璐, 王晓玲, 郭鹏. 国内外基于真实世界数据的药品上市后安全性主动监测系统对比分析[J]. 中国药物警戒, 2024, 21(8): 892-899.
[6]	程毅菁, 李涛, 刘军廷, 黄贵民, 钟旭丽, 林爱华, 潘守东, 李龙, 白东升, 占小俊, 刘振江, 任韡, 聂晓璐, 邰隽. 基于真实世界数据的注射用尖吻蝮蛇血凝酶儿童用药安全性评价[J]. 中国药物警戒, 2024, 21(7): 787-790.
[7]	潘知玉, 朱健, 于亚南, 刘骏, 姜燕华, 钱真真, 吴广, 王忠, 武红莉, 荆志伟. 3010例芪蛭通络胶囊的真实世界安全性研究[J]. 中国药物警戒, 2024, 21(6): 660-665.
[8]	汪春楠, 秦诗如, 章萌, 宋海波, 刘俊昌, 李戈, 孙凤. 多中心真实世界数据评价药品安全性研究进展[J]. 中国药物警戒, 2024, 21(6): 703-708.
[9]	王书波, 焦婷婷, 董洪亮, 王百聆, 李辉. 基于真实世界数据研究注射用伏立康唑致急性肾损伤的危险因素建立预测模型及验证[J]. 中国药物警戒, 2024, 21(5): 567-571.
[10]	孙雪林, 杜娇, 谭琴, 张亚同, 胡欣. 真实世界维生素注射剂用药模式分析[J]. 中国药物警戒, 2024, 21(10): 1125-1129.
[11]	史卜文, 李利寻, 谢雁鸣, 王志飞, 王淇. 真实世界喜炎平注射液治疗3846例细菌性肠道感染患者临床用药特征分析[J]. 中国药物警戒, 2023, 20(9): 1017-1021.
[12]	赵燕, 刘文博, 赵一飞, 李栋, 郑立佳, 宋雅娜, 赵玉娟, 董放. 患者登记研究应用于医疗器械监管科学的实践研究与思考[J]. 中国药物警戒, 2023, 20(4): 423-427.
[13]	杜莹, 谢雁鸣, 王连心, 耿洪娇, 李向杰. 真实世界连花清瘟胶囊（颗粒）适应证人群临床特征及联合用药分析[J]. 中国药物警戒, 2023, 20(3): 296-300.
[14]	杜莹, 赵晓晓, 谢雁鸣, 余小康. 基于真实世界使用榄香烯乳状注射液影响肝功能的倾向性评分分析[J]. 中国药物警戒, 2023, 20(2): 191-195.
[15]	王嘉熙, 郭代红, 张博, 李伯妍, 郭海丽. 116097例氟比洛芬酯用药人群的急性肾损伤自动监测研究及危险因素分析[J]. 中国药物警戒, 2023, 20(2): 201-205.

真实世界喜炎平注射液治疗病毒性肠道感染数据挖掘及分析

Data mining and network analysis of Xiyanping injection in the treatment of viral intestinal infection based on the real world

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics