中国药物警戒 ›› 2019, Vol. 16 ›› Issue (7): 436-441.

• 安全性评价与合理用药 • 上一篇    下一篇

我院2011~2018年6种造影剂的不良反应发生及预后回顾性分析

李晓丹, 张阳鑫, 刘琛, 白向荣, 闫素英*   

  1. 首都医科大学宣武医院药剂科,北京 100053
  • 收稿日期:2019-08-06 修回日期:2019-08-06 出版日期:2019-07-20 发布日期:2019-08-06
  • 通讯作者: 闫素英,女,主任药师,副教授·硕导,药事管理及临床药学。E-mail：yansuying10@sina.cn
  • 作者简介:李晓丹,女,药师,药品质量管理。

Retrospective Analysis of Adverse Reactions and Prognosis of Six Contrast Agents from 2011 to 2018

LI Xiaodan, ZHANG Yangxin, LIU Chen, BAI Xiangrong, YAN Suying*   

  1. Department of Pharmacy, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
  • Received:2019-08-06 Revised:2019-08-06 Online:2019-07-20 Published:2019-08-06

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摘要： 目的 探究造影剂在临床应用中的问题及药品不良反应的发生特点,为临床合理使用造影剂提供基础数据和策略。方法 回顾性分析我院2011年1月至2018年6月期间含钆及碘造影剂相关的药品不良反应报告,估算造影剂相关ADR发生率,分析ADR患者的性别、年龄、严重程度、累及系统及ADR发生时间分布。结果 我院2011年1月至2018年6月期间含钆及碘造影剂相关的药品不良反应报告共177例,涉及男性106例（59.9%）,女性71例（40.1%）,其中8例为严重不良反应。药品不良反应主要表现为皮肤及附件损害、消化系统损害、神经系统损害、过敏样反应等。72例（40.7%）药品不良反应发生在用药后10分钟以内。结论 含钆对比剂的不良反应发生率明显高于碘对比剂,提示临床应关注,在给药过程中及停药后均应密切观察患者的情况,一旦发生药品不良反应,需立即停药并采取对症治疗措施。

关键词: 造影剂, 药品不良反应, 预防措施

Abstract: Objective To find problems of contrast agents used in clinic and the characteristics of contrast agent-induced adverse drug reactions (ADRs), providing baseline data and strategies for rational use of contrast agents. Methods The study retrospectively analyzed the adverse drug reaction(ADR) reports of gadolinium and iodine contrast agents from January 2011 to June 2018 in Xuanwu Hospital. It estimated the incidence of contrast-related ADR. It also described ADR-related patients' gender, age, severity, organs and occurrence time. Results In our hospital, there were 177 cases of adverse drug reactions related to gadolinium and iodine contrast agents from January 2011 to June 2018. In 177 cases of contrast agent-induced ADRs, there were 106 males (59.9%) and 71 females (40.1%). There were 8 cases of severe ADRs. Clinical manifestations were skin and appendages disorders, gastrointestinal disorders, nervous system disorders and allergic reaction.72 (40.7%) cases of ADRs happened in 10 minutes after medication. Conclusion The adverse reaction incidence of gadolinium contrast agents is significantly higher than that of iodine contrast agents. Patients should be under close attention during and after medication period. Once adverse drug reaction occurred, strategies such as stopping the medication and treatment should be quickly undertaken.

Key words: contrast agent, adverse drug reaction, preventive measures、

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