中国药物警戒 ›› 2019, Vol. 16 ›› Issue (3): 157-163.

• 安全性评价与合理用药 • 上一篇    下一篇

基于WHOART的我国心血管系统药物致不良反应病例报告分析

林鑫, 郭进京, 任慧玲*   

  1. 中国医学科学院医学信息研究所,北京 100020
  • 收稿日期:2018-12-11 修回日期:2020-06-28 出版日期:2019-03-20 发布日期:2019-04-17
  • 通讯作者: 任慧玲,女,硕士,研究馆员·硕导,医学术语标准化。E-mail：ren.huiling@imicams.ac.cn
  • 作者简介:林鑫,女,在读硕士,医学术语标准化。
  • 基金资助:
    中国医学科学院医学与健康科技创新工程项目（2017-I2M-3-014）：中文临床医学术语系统构建研究

Analysis of Adverse Drug Reaction Case Reports Induced by Cardiovascular Drugs Based on WHOART

LIN Xin, GUO Jinjing, REN Huiling*   

  1. Institute of Medical Information, Chinese Academy of Medical Sciences, Beijing 100020, China
  • Received:2018-12-11 Revised:2020-06-28 Online:2019-03-20 Published:2019-04-17

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摘要： 目的 分析我国心血管系统药物致药品不良反应（adverse drug reaction,ADR）的发生情况及其严重程度的可能影响因素。方法 通过国家人口与健康科学数据共享服务平台提供的1 201条心血管药物致ADR记录,基于《马丁代尔药物大典》和WHOART,利用Jieba分词对ADR症状进行提取与清洗,同时将其他各个字段进行规范化处理,并对ADR记录中患者的性别与年龄、给药途径等数据进行统计分析。结果 在所有记录中,男性患者略多于女性且多发于50~79岁;静脉用药引起的ADR最多且多发于给药10 min内;主要ADR症状是胸闷;中成药引起的ADR最多,其次为抗心律失常药;多数ADR较轻微且给药途径对ADR严重程度影响显著。结论 本研究的方法可以有效地对心血管系统药物致ADR进行分析,临床医护人员应加强对心血管系统药物致ADR的监测,确保临床合理用药,规范患者的心血管用药安全。

关键词: WHO药品不良反应术语集, 心血管系统药物, 药品不良反应, 分析, 病例报告

Abstract: Objective To analyze the occurrence of adverse drug reactions (ADRs) induced by cardiovascular drugs in China and the possible influencing factors of their severity. Methods 1 201 case records of ADRs induced by cardiovascular drugs were obtained from National Science Data Sharing Platform for Population and Health. Based on Martindale: the Complete Drug Reference and WHOART, the ADR symptoms were extracted and cleaned by Jieba. Other fields were normalized simultaneously, and the patients' genders, ages, routes of administration and so on in ADR records were statistically analyzed. Results In all records, male patients were slightly more than female patients and mostly aged 50~79 years; ADRs induced by intravenous administration were the most common and occurred within 10 minutes of administration; the main ADR symptoms were chest tightness. Traditional Chinese medicines were the most common drugs which induced ADRs, followed by anti-arrhythmic drugs. Most ADRs were mild and the route of administration had a significant effect on the severity of ADRs. Conclusion The method proposed in this study could effectively analyze the ADRs induced by cardiovascular drugs, and clinical medical staffs should strengthen the monitoring of ADRs induced by cardiovascular drugs, ensure rational clinical use and standardize the safety of cardiovascular drug use.

Key words: WHOART, cardiovascular drugs, adverse drug reaction, analysis, case report

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