5-羟甲基糠醛的药理和毒理研究进展

中国药物警戒 ›› 2018, Vol. 15 ›› Issue (4): 210-215.

• 过敏原非临床安全性评价专栏 • 上一篇下一篇

5-羟甲基糠醛的药理和毒理研究进展

李恩灿¹, 贺玖明², 靳洪涛^1,3,*, 林铌^1,4

1中国医学科学院北京协和医学院药物研究所新药安全评价研究中心,北京100050;
2中国医学科学院北京协和医学院药物研究所天然药物活性物质与功能国家重点实验室,北京 100050;
3北京协和建昊医药技术开发有限责任公司,北京 100176;
4首都医科大学,北京 100069

收稿日期:2018-05-29 修回日期:2018-05-29 出版日期:2018-04-20 发布日期:2018-05-29
通讯作者: 靳洪涛,男,副研究员,药物安全性评价及药物毒性作用机制。E-mail：jinhongtao@imm.ac.cn
作者简介:李恩灿,女,在读硕士,药物毒理作用机制。
基金资助:
国家自然科学基金（81773996）：小分子物质5-HMF及其二聚体OMBF作为变应原的毒性与机制研究; 北京协和医学院“协和青年科研基金”（3332015135）：5-HMF及其聚合物的免疫毒性及机制探索研究

Research Progress of Pharmacological Activity and Toxicity of 5-Hydroxymethylfurfural

LI En-can¹, HE Jiu-ming², JIN Hong-tao^1,3,*, LIN Ni^1,4

1New Drug Safety Evaluation Center, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;
2State Key Laboratory of Active Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;
3Beijing Union-Genius Pharmaceutical Technology Co., Ltd, Beijing 100176, China;
4Capital Medical University, Beijing 100069, China

Received:2018-05-29 Revised:2018-05-29 Online:2018-04-20 Published:2018-05-29

摘要/Abstract

摘要： 目的了解并总结5-羟甲基糠醛（5-HMF）的药理和毒理研究的最新进展。方法列举5-HMF常见的药理作用及毒性,搜集并整理了已有的5-HMF的研究资料,以表明现阶段5-HMF的研究方向,最后强调了5-HMF含量检测和限量控制的必要性。结果 5-HMF同时具有药理活性和毒性,且广泛存在于食物和药物中,它最终是否对人体有害,还要取决于不同的暴露途径、暴露剂量和频率,因此5-HMF的毒性应该得到人们更多的关注。结论 5-HMF的安全性研究对含有5-HMF的食物和药物的质控和安全应用具有指导意义。

关键词: 5-羟甲基糠醛（5-HMF）, 药理活性, 毒性, 研究进展

Abstract: Objective To understand and summarize the recent progress in the pharmacology and toxicology research of 5-hydroxymethylfurfural(5-HMF). Methods The author listed the common pharmacological effects and toxicity of 5-HMF, and collected and analyzed the existing research data which showed the research direction of 5-HMF at the present stage, then emphasized the necessity of 5-HMF content detection and limited control. Results 5-HMF has both pharmacological activity and toxicity, and is widely present in food and medicine, and ultimately whether it is harmful to the human body or not depends on the route of exposure, the dose and frequency of exposure, therefore, people should pay more attention to the toxicity of 5-HMF. Conclusion The safety evaluation of 5-HMF may provide guidance for the quality control and safe application of 5-HMF-containing foods and drugs.

Key words: 5-hydroxymethylfurfural (5-HMF), pharmacological activity, toxicity, research progress

中图分类号:

R965

李恩灿, 贺玖明, 靳洪涛, 林铌. 5-羟甲基糠醛的药理和毒理研究进展[J]. 中国药物警戒, 2018, 15(4): 210-215.

LI En-can, HE Jiu-ming, JIN Hong-tao, LIN Ni. Research Progress of Pharmacological Activity and Toxicity of 5-Hydroxymethylfurfural[J]. Chinese Journal of Pharmacovigilance, 2018, 15(4): 210-215.

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5-羟甲基糠醛的药理和毒理研究进展

Research Progress of Pharmacological Activity and Toxicity of 5-Hydroxymethylfurfural

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