中国药物警戒 ›› 2017, Vol. 14 ›› Issue (4): 242-245.

• 安全性评价与合理用药 • 上一篇    下一篇

我院907例抗肿瘤药物不良反应分析

韦灵玉, 邱晓春, 周彦来, 王作荣   

  1. 贵州省肿瘤医院,贵州 贵阳 550001
  • 收稿日期:2017-07-05 修回日期:2017-07-05 出版日期:2017-04-20 发布日期:2017-07-05
  • 通讯作者: 邱晓春,女,本科,副主任药师,医院药学。E-mail：chunqiu218@126.com
  • 作者简介:韦灵玉,女,硕士,主管药师,临床药学。

Analysis of 907 Cases of Adverse Drug Reactions Induced by Antineoplastic Drugs

WEI Ling-yu, QIU Xiao-chun, ZHOU Yan-lai, WANG Zuo-rong   

  1. Guizhou Provincial Tumor Hospital, Guizhou Guiyang 550001, China
  • Received:2017-07-05 Revised:2017-07-05 Online:2017-04-20 Published:2017-07-05

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摘要： 目的 探讨肿瘤患者应用抗肿瘤药物不良反应发生的规律及特点,为临床合理用药提供依据。方法 收集我院2011年至2016年上报至国家药品不良反应监测中心的907例抗肿瘤药品不良反应（ADR）报告,从患者的基本情况、发生时间、涉及药品、给药途径、ADR累及器官或系统及临床表现、治疗及结局等方面进行回顾性分析。结果 907例抗肿瘤药物不良反应中,男女比例为1.01:1;发生ADR的患者多数（74.42%）为40岁以上的中老年人;ADR多数（82.58%）发生在给药后0~7 d以内;ADR报告涉及抗肿瘤药8大类,其中顺铂居首位;抗肿瘤药物以合并使用为主（90.86%）,合并用药前3位为注射用顺铂、多西他赛注射液、紫杉醇注射液;静脉滴注给药途径发生ADR比例最高（74.54%）;不良反应涉及的系统以血液系统、胃肠系统损害和皮肤及其附件损害最为多见;在患者转归方面,好转和痊愈共占87.10%。结论 临床应用抗肿瘤药时,应加强监护以减少ADR的发生,及时正确地处理以降低其危害,提高用药的安全性。

关键词: 抗肿瘤药物, 不良反应, 合理用药, 监测, 骨髓抑制

Abstract: Objective To study the characteristics and regularities of adverse drug reactions (ADR) induced by antineoplastic drugs and provide references for the clinical rational use of antineoplastic drugs. Methads 907 reports of ADR induced by antineoplastic drugs from 2011 to 2016 in our hospital were retrospectively analyzed in terms of patient’s general information, drug varieties, routes of administration, occurrence time, involved organs-systems, clinical manifestations, treatments and outcomes. Results There is no difference between male and female. ADR of antineoplastic drugs mainly (74.42%) occurred in patients aged 40 years above. Most (82.58%) cases happened in 0~7 days after medication. 8 classes of antineoplastic drugs were involved, among which cisplatin occupied the top. Drug combinations were the main use of anti-tumor drugs (90.86%). Cisplatin for injection, dorsey injection, paclitaxel injection were the top three of combinations. Intravenous dripping was the main route of administration (74.54%). The blood system was the most involving system, followed by the digestive system, skin and its accessories. Most patients were improved or cured after given the appropriate treatment (87.10%). Conclusion Intensive cares should be adopted to reduce the occurrence of ADR when antineoplastic drugs were applied. Processing of ADR timely could reduce the harm and improve the safety of drug use.

Key words: antineoplastic drug, adverse reaction, rational use of drug, monitoring, bone marrow suppression

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