复方丹参滴丸药理作用及代谢研究进展

中国药物警戒 ›› 2016, Vol. 13 ›› Issue (11): 682-685.

复方丹参滴丸药理作用及代谢研究进展

常虹¹, 李正国¹, 杨庆国², 吴世福^{3*, *}

1.济宁市食品药品检验检测中心,山东济宁 272100;
2.济宁市兖州区食品药品监督管理局,山东济宁 272100;
3.山东省药品不良反应监测中心,山东济南 250014

收稿日期:2016-12-05 修回日期:2016-12-05 出版日期:2016-11-20 发布日期:2016-12-05
作者简介:常虹,女,在读硕士,主管药师,药品不良反应监测与评价。

Research Advance on Pharmacological Effects and Metabolism of Fufangdanshen Dripping Pills

CHANG Hong¹, LI Zheng-guo¹, YANG Qing-guo², WU Shi-fu^{3, *}

1.Jining Institute for Food and Drug Control, Shandong Jining 272100, China;
2.Food and Drug Administration of Jining Yanzhou District, Shandong Jining 272100, China;
3.Shandong Center for ADR Monitoring, Shandong Jinan 250014, China

Received:2016-12-05 Revised:2016-12-05 Online:2016-11-20 Published:2016-12-05
Contact: 吴世福,男,硕士,副主任药师,药品不良反应监测与评价。E-mal:1565013258@qq.com。

摘要/Abstract

摘要： 目的总结了复方丹参滴丸的药理作用及体内代谢研究的现状。方法检索中国知网、pubmed等数据库,查阅相关著作,对近20年来国内外发表的文献进行梳理,总结分析复方丹参滴丸有效成分及质量控制方法、体内代谢、药理作用等方面研究进展,着重叙述了复方丹参滴丸对药物代谢酶的影响。结果与结论复方丹参滴丸化学成分和质量控制方法研究较为成熟;其药理作用主要为增强细胞活力、改善组织缺血、抑制血小板聚集等;滴丸中主要单体成分大部分抑制CYP450s,只有极少部分对相应酶有诱导作用,而制剂整体作用不是单体成分的简单加和,其对药物代谢酶的影响是目前研究的难点和热点。

关键词: 复方丹参滴丸, 代谢, 药理作用

Abstract: Objective To summarize the current states of pharmacological effects and metabolic research about Fufangdanshen dripping pills. Methods By combing articles published at home and abroad in recent 20 years, the research progress of the effective components and quality control methods, metabolism and pharmacological effects were summarized, the effects of Fufangdanshen dripping pills on drug metabolizing enzymes were described specially. Results and Conclusion Chemical constituents and quality control methods of Fufangdanshen dripping pills have been maturely studied. Its main pharmacological effects are enhancing cell viability, improving tissue ischemia, inhibiting platelet aggregation and so on. Most of the main monomer components in the dropping pills inhibit CYP450s, only a very small part has an induction effect, and the overall effect of the preparation is not a simple addition. It is a difficult and hot topic to further expound the action mechanisms about the effects of Fufangdanshen dripping pills on drug metabolizing enzymes.

Key words: Fufangdanshen dripping pill, metabolism, pharmacological effect

中图分类号:

R965

常虹, 李正国, 杨庆国, 吴世福. 复方丹参滴丸药理作用及代谢研究进展[J]. 中国药物警戒, 2016, 13(11): 682-685.

CHANG Hong, LI Zheng-guo, YANG Qing-guo, WU Shi-fu. Research Advance on Pharmacological Effects and Metabolism of Fufangdanshen Dripping Pills[J]. Chinese Journal of Pharmacovigilance, 2016, 13(11): 682-685.

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