中国药物警戒 ›› 2010, Vol. 7 ›› Issue (9): 554-555.

• 药品不良反应监测 • 上一篇    下一篇

SSRI和SNRI类抗抑郁药的不良反应

张英1,崔向丽2*,杨萍2,贾颖2,刘静2,潘华3,赵志刚2   

  1. 1.首都医科大学附属北京天坛医院药品设备物资管理部,北京 100050；
    2.首都医科大学附属北京天坛医院药剂科,北京 100050；
    3.首都医科大学附属北京天坛医院神经内科,北京 100050
  • 收稿日期:2010-06-23 修回日期:2016-03-09 出版日期:2010-09-08 发布日期:2016-03-09
  • 通讯作者: 崔向丽,女,主管药师,临床合理用药与不良反应监测。 E-mail:cui10@163.com
  • 作者简介:张英,女,主管药师,药品采购与管理。

Adverse Drug Reaction Induced by Antidepressants of SSRI and SNRI

ZHANG Ying1 ,CUI Xiang-li2* ,YANG Ping2, JIA Ying2, LIU Jing2, PAN Hua3 ,ZHAO Zhi-gang2   

  1. 1.Pharmaceutical Equipment and Material Management, Tiantan Hospital, Capital Medical University, Beijing 100050 China;
    2.Department of Pharmacy, Tiantan Hospital, Capital Medical University, Beijing 100050 China;
    3.Neurology Department, Tiantan Hospital, Capital Medical University, Beijing 100050, China
  • Received:2010-06-23 Revised:2016-03-09 Online:2010-09-08 Published:2016-03-09

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摘要： 目的 研究SSRI 和SNRI 类抗抑郁药不良反应的临床表现和处理措施,为临床医师合理用药提供参考。方法 收集我院2010 年上半年神经内科门诊使用SSRI 或SNRI 类抗抑郁药出现不良反应的24 例抑郁或焦虑病例,分析其具体不良反应临床表现和相应的处理措施。结果SSRI/SNRI最常见的不良反应是胃肠道反应,其他少见的有精神症状、自主神经功能障碍和椎体外系反应等。结论 尽管SSRI 和SNRI 都是比较安全的抗抑郁药物,临床医师应该注意监测其不良反应,并掌握处理措施。

关键词: 5-羟色胺再摄取抑制剂, 5-羟色胺/去甲肾上腺素再摄取抑制剂, 不良反应, 处理措施

Abstract: Objective To study the clinical syndrom of adverse drug reaction(ADR) induced by SSRI or SNRI, and the treatment of ADR. Methods 24 depression cases with ADR induced by SSRI or SNRI were collected in neurological outpatients from January,2010 to June,2010, we analysised the clinical syndroms of ADR induced by SSRI or SNRI, and de-scribed the treatment of different ADR. Results The most common ADR is Gastrointestinal tract reaction, less comman ADR are Psychiatric symptoms, autonomic nervous system dysfunction and extrapyramidal reaction. Conclusion Although SSRI and SNRI are most safe antidepressants, neurologists should pay much attention to their ADR, and grasp the treatment measures.

Key words: selective serotonin reuptake inhibitors(SSRI), serotonin/norepinephrine reuptake inhibitors(SNRI), adverse drug reaction(ADR), treatment measures

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