中国药物警戒 ›› 2010, Vol. 7 ›› Issue (12): 710-712.

• 基础研究 • 上一篇    下一篇

鬼针草总黄酮对实验性脑出血大鼠脑损伤的保护作用

包雪鹦1, 齐欣1,胡媛1,刘玉祥1,解晶1,曲极冰2   

  1. 1. 解放军第208 医院神经内科,吉林长春130062；
    2.吉林大学白求恩医学院药理学系,吉林长春130021
  • 收稿日期:2010-10-01 修回日期:2016-03-09 出版日期:2010-12-08 发布日期:2016-03-09
  • 通讯作者: 曲极冰,男,教授,药理学研究。 E-mail: qjbjldx@126.com
  • 作者简介:包雪鹦,女,主任医师,神经内科学研究。

N europrotection of Total Flavones of Bidens Bipinnata L. on Brain Damage Following Experimental Intracerebral Hemorrhage in Rats

BAO Xue-ying1 ,QI Xin1 HU Yuan1, LIU Yu-xiang1 ,XIE Jing1, QU Ji-bing2   

  1. 1.Department of Neurology, The 208th Hospital of PLA, Jilin Changchun 130062;
    2.Department of Pharmacology, School of Basic Medicine, Jilin University, Jilin Changchun 130021
  • Received:2010-10-01 Revised:2016-03-09 Online:2010-12-08 Published:2016-03-09

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摘要： 目的 观察鬼针草总黄酮（TFB）对大鼠实验性脑出血后脑组织损伤的影响,探讨其对大鼠脑损伤的保护机制。方法 采用大脑立体定位技术,取不抗凝血液50 L缓慢注入尾状核,建立大鼠实验性脑出血模型,观察TFB 对脑组织含水量、全血粘度及脑匀浆中超氧化物歧化酶（SOD）、丙二醛（MDA）、一氧化氮（NO）等生化指标的影响。结果 TFB 高、中、低剂量组均能显著改善脑出血大鼠脑含水量、全血粘度,高、中剂量组能明显升高脑组织SOD 活性,降低MDA、NO 含量（P ＜0.05）。结论TFB 对实验性脑出血大鼠脑损伤的保护作用可能与其减轻脑水肿、改善血肿周围组织的微循环状态、减轻细胞膜脂质过氧化损伤、抑制NO 的产生有关。

关键词: 鬼针草总黄酮, 实验性脑出血, 氧自由基, 脑水肿, 全血粘度

Abstract: Objective To investigate the neuroprotective and mechanism of total flavones of bidens bipinnata L.(TFB) on brain damage following experimental intracerebral hemorrhage in rats. Methods Experimental intracerebral hemorrhage was induced in rats through infusion 50μL of fresh autologous blood drawn into the caudate uncleus. The brain water content, whole blood viscosity and the level of SOD, MDA and NO were measured. Results TFB (100mg·kg-1、30mg·kg-1、10mg·kg-1) significant improve the brain water content and status whole blood viscosity. The level of MDA, NO was lower, and the level of SOD was obviously higher in high-, middle-dose TFB group in cerebral tissue( P<0.05). Conclusion TFB has evident protective effect on brain damage after experimental intracerebral hemorrhage in rats, which maybe related to diminished cerebral edema, improve the microcirculation status of peri-hematomal penumbra, the increased the ability of decreased lipid peroxidation, inhibited production of NO.

Key words: Key word: Total Flavones of Bidens bipinnata L. (TFB), experimental intracerebral hemorrhage, oxygen -derived free radicals, cerebral edema, whole blood viscosity

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