中国药物警戒 ›› 2010, Vol. 7 ›› Issue (7): 439-441.

• 药品不良反应监测 • 上一篇    下一篇

212例氟喹诺酮不良反应/事件分析

丁庆明1,2, 徐小华2, 陆进2   

  1. 1中国医学科学院 北京协和医学院,北京 100073;
    2中日友好医院药学部,北京 100029
  • 收稿日期:2016-02-22 修回日期:2016-02-22 出版日期:2010-07-08 发布日期:2016-02-22
  • 作者简介:丁庆明,男,主管药师,药物警戒。

Analysis of 212 Adverse Drug Reaction/Event Reports of Fluoroquinolone

DING Qing-ming1,2, XU Xiao-hua2, LU Jin2   

  1. 1Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100073, China;
    2Department of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, China
  • Received:2016-02-22 Revised:2016-02-22 Online:2010-07-08 Published:2016-02-22

PDF (PC)

191

摘要： 目的 分析氟喹诺酮药物不良反应发生的一般规律及其特点,为临床合理使用提供依据。方法 采用回顾性研究方法,对2004至2009年中日友好医院上报的212例氟喹诺酮药品不良反应/事件报告进行统计分析。结果 不良反应/事件以静脉剂型为主（85.38%）、女性患者比例高（72.64%）,首次用药后出现症状的比例高（90.09%）,主要表现为神经系统、皮肤及其附件的临床症状,多数患者在停药后1天内康复或明显好转。结论 应重视氟喹诺酮药物首次用药后的监护,以及新的、罕见不良反应的正确诊断和治疗。

关键词: 氟喹诺酮, 药品不良反应/事件, 分析

Abstract: Objective To analyze relevant factors of the adverse drug reaction/event(ADR/ADE) induced by Fluoro-quinolons. Methods 212 ADR/ADE reports collected by Fluoroquinolones in China-Japan Friendship Hospital from 2004 to 2009 have been analyzed retrospectively. Results ADRs/ADEs induced by injection were most. The female had higher probability of occurrence. The clinical manifestation of ADR/ADE mainly involved system damage, skin and appendages damage, and digestive system damage. Most ADR/ADE cases happened in one day after medication. Conclusion The patients should be intensively warded after the first medication. It's important to diagnose correctly and disposal in time to the new ADR/ADE.

Key words: fluoroquinolone, adverse drug reaction/event(ADR/ADE), analysis

中图分类号: