中国药物警戒 ›› 2010, Vol. 7 ›› Issue (3): 162-163.

• 药品不良反应监测 • 上一篇    下一篇

216例氟喹诺酮类药品不良反应的回顾性分析

郭晓莺, 李青山, 程景民*   

  1. 山西医科大学,山西 太原 030001
  • 收稿日期:2016-02-19 修回日期:2016-02-19 出版日期:2010-03-08 发布日期:2016-02-19
  • 通讯作者: 程景民,男,副教授,药品安全管理。E-mail:7287@163.com
  • 作者简介:郭晓莺,女,副主任药师,药品不良反应监测。

Retrospectively Survey and Analysis of the Adverse Drug Reaction in 216 Patients Using Fluoroquinolones

GUO Xiao-ying, LI Qing-shan, CHENG Jing-min*   

  1. Shanxi Medical University, Shanxi Taiyuan 030001, China
  • Received:2016-02-19 Revised:2016-02-19 Online:2010-03-08 Published:2016-02-19

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摘要： 目的 探讨氟喹诺酮类药品不良反应的临床表现及其分布情况。方法 对临床使用氟喹诺酮类药物治疗出现不良反应的患者采用回顾性调查与分析。结果 男性患者明显多于女性患者,不良反应主要发生在神经系统、过敏反应、皮肤及其附件,局部和口服的不良反应发生率明显低于肌内注射和静脉注射。结论 对于氟喹诺酮类药物应合理使用,严格掌握其适应证、禁忌证及其单独与联合用药量,避免不合理的联合用药,明确其发生不良反应的机制,降低其不良反应发生率。

关键词: 氟喹诺酮类药物, 不良反应, 回顾性分析

Abstract: Objective By analyzing 216 advense drug reaction reports received in a hospital,we explore the clinical manifestations of fluoroquinolones' adverse reactions and their distribution. Mothods In this article we retrospectively survey and analyze the adverse reactions that occur in patients using fluoroquinolones. Results We find Male patients significantly more than female patients, adverse events occurred mainly in the nervous system, allergic reactions, skin and its annexes, and local and oral incidence of adverse reactions was significantly lower than intramuscular injection and intravenous injection.Conlusion Fluoroquinolones should be rationally used. We should strictly control their in-dications, con-traindications and the quantity of separate and combined to avoid unreasonable use. We should make its mechanism clear to decrease the occurrence rate of adverse reactions and play its clinical efficacy better.

Key words: fluoroquinolones, adverse drug reaction, retrospective analysis

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