中国药物警戒 ›› 2010, Vol. 7 ›› Issue (2): 119-121.

• 药品不良反应监测 • 上一篇    下一篇

1672例神经系统药品不良反应报告分析

彭丹冰, 赵燕, 程蓉, 查勇, 林卫   

  1. 贵州省药品不良反应监测中心,贵州 贵阳 550004
  • 收稿日期:2016-02-19 修回日期:2016-02-19 出版日期:2010-02-08 发布日期:2016-02-19
  • 作者简介:彭丹冰,女,博士,药品不良反应监测。

Analysis of 1 672 Cases of Adverse Drug Reaction of Nervous System

PENG Dan-bing, ZHAO Yan, CHENG Rong, ZHA Yong, LING Wei   

  1. Guizhou Center for ADR Monitoring, Guizhou Guiyang 550004, China
  • Received:2016-02-19 Revised:2016-02-19 Online:2010-02-08 Published:2016-02-19

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摘要： 目的 分析神经系统药品不良反应发生的特点及规律,为临床合理用药提供参考。方法 采用回顾性研究方法,对贵州省2006年1月1日~2008年12月31日收集的1 672例神经系统药品不良反应报告进行分析。结果 神经系统不良反应报告占全部报告的10.45%;患者男女性别比为1 1.04;19~59岁患者占73.10%;药品不良反应累及中枢及外周神经系统（705例）和交感及副交感神经系统（1 206例）;交感及副交感神经系统损害的临床表现主要为心悸、呕吐和腹泻,中枢及外周神经系统损害的临床表现主要为头晕、头痛和肢体麻木;涉及药物22类,抗感染药物居首位;静脉给药发生不良反应居首位,为956例（57.18%）。结论 应重视药源性神经系统损害,及时发现、诊治和预防药源性神经系统不良反应。

关键词: 神经系统, 药品不良反应, 报告, 分析

Abstract: Objective To investigate the situation of adverse drug reaction(ADR) of nervous system(NS), offer references for rational application in clinical ptactice. Methods 1 672 reports collected by Guizhou Center for ADR monitoring from Janury,1st 2006 to December, 31th 2008 were analyzed using retrospective study method. Results The reports of ADR of NS accounted for 10.45% in all reports. The ratio of male to famal was 1 1.04. 19~59 years old account for 73.10%. The NS lesion included sympathetic and parasympathetic system(1 206 cases), central and periphersl nervous system .The clinical manifestations of the former mainly were palpitation, vomiting and diarrhea, the latte's mainly were dizziness, headache and local numbness. These ADR cases were induced by 22 kinds of drugs and most of them caused by cephalosporins. Intravenous injection is the main way for administration. Conclusion We should pay attention to drug-induced damage to the NS, timely detect, diagnose, treatment and prevent ADR of NS.

Key words: nervous system, adverse drug reaction(ADR), report, analysis

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