中国药物警戒 ›› 2010, Vol. 7 ›› Issue (1): 37-40.

• 综述 • 上一篇    下一篇

基于功效和物质基础的半夏毒性研究进展

孙蓉1, 黄伟2, 鲍志烨2, 吕莉莉1   

  1. 1山东省中医药研究院,山东 济南 250014;
    2山东中医药大学,山东 济南 250355
  • 收稿日期:2016-02-18 修回日期:2016-02-18 出版日期:2010-01-08 发布日期:2016-02-18
  • 作者简介:孙蓉,女,研究员,中药药理与毒理研究与评价。
  • 基金资助:
    国家973计划中医基础理论专项,确有疗效的有毒中药科学应用关键问题的基础研究（项目编号：2009CB522800）; 有毒中药的毒性与功效、证候关系的基础研究（课题编号：2009CB522802）; 山东省科技平台建设项目课题（课题编号：2008GG2NS02021）; 山东省中医局科技发展计划课题（课题编号：2007-119）

Research Development on Toxicity of Rhizoma Pinelliae Related to Efficacy and Chemical Material Basis

SUN Rong1, HUANG Wei2, BAO Zhi-ye2, LV Li-li1   

  1. 1Shandong Research Academy of TCM Shandong Jinan 250014, China;
    2Shandong University of Traditional Chinese Medicine, Shandong Jinan 250355,China
  • Received:2016-02-18 Revised:2016-02-18 Online:2010-01-08 Published:2016-02-18

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摘要： 目的 为进行功效和毒性导向下的化学成分分离、控制和功效与毒性成分的“量效关系”和“量毒关系”研究提供文献依据和研究思路。方法 对半夏近十几年来国内外相关文献进行整理、分析与归纳。结果 半夏针对功效、物质基础和毒性的研究都局限在单一学科之间,缺乏两者之间甚至相互间的关联性研究。结论 只有在半夏功效表达和功效物质基础分离与控制的过程中,进行毒性的研究和毒性物质基础的安全控制,才能提出切合半夏临床使用过程中不良反应预警方案和早期诊疗措施,保证半夏临床用药安全。

关键词: 半夏, 功效, 毒性, 物质基础

Abstract: Objective To provide literature evidences asis and research ideas of efficacy and toxicity of the chemical composition of guided separation,control and efficacy, and the research on the“dose-effect relationship” and “dose-toxicity relationship” about the toxicial components. Methods References in the last decades both at home and abroad about Rhizoma Pinelliae were collated, analyzed and summarized. Results The research on Rhizoma Pinelliae about the toxicial effects based on the efficacy and the material basis are confined to single disciplines. Between and even mutual relevance studies are very lack of. Conclusion The research on Rhizoma Pinelliae about the toxicity and margin of safety control based on the chemical separation and quality control about the effective material basis combined with the process of the effectiveness of expression, so as to provide consummating safety standards and putting forward early-warning scheme of adverse reaction, the early diagnosis and treatment measures that can be referred to clinical usage. Rhizoma Pinellia will be ensured to use safety as a clinical drug.

Key words: Rhizoma Pinelliae, efficacy, material basis, toxicity

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