中国药物警戒 ›› 2019, Vol. 16 ›› Issue (7): 399-403.

• 中药药物警戒与合理用药专栏 • 上一篇    下一篇

《本草纲目》药物用毒警戒思想研究

石琳1,2, 刘欣1,2, 张冰1,2,*   

  1. 1 北京中医药大学,北京 100029;
    2 北京中医药大学中药药物警戒与合理用药研究中心,北京 100029
  • 收稿日期:2019-08-06 修回日期:2019-08-06 出版日期:2019-07-20 发布日期:2019-08-06
  • 通讯作者: 张冰,女,教授,主任医师·博导,中药药物警戒与合理用药研究、中药药性研究。E-mail：zhangbing6@263.net
  • 作者简介:石琳,女,博士,副研究员,中药药物警戒与合理用药研究。
  • 基金资助:
    国家自然科学基金（81874349）：辛热类有毒中药风险-效益阈与效毒机制研究

Study on Use of Drug Toxicity in Pharmacovigilance Thought of the Compendium of Materia Medica

SHI Lin1,2, LIU Xin1,2, ZHANG Bing1,2,*   

  1. 1 Beijing University of Chinese Medicine, Beijing 100029, China;
    2 Center for Pharmacovigilance and Rational Use of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
  • Received:2019-08-06 Revised:2019-08-06 Online:2019-07-20 Published:2019-08-06

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摘要： 目的 从药物警戒的角度对《本草纲目》进行研究,挖掘整理其中蕴含的中药药物警戒思想和实践经验。方法 用传统文献和数据挖掘的研究方法,对《本草纲目》190余万字文献内容进行筛选,重点总结归纳其与用毒警戒相关的内容。结果 《本草纲目》中记载了大量在药物使用的不同环节,以增加用药安全或避免出现不良反应为目的 的内容和方法。结论 《本草纲目》的用毒警戒思想主要体现在：注重配伍饮食禁忌,提倡理性用毒;重视煎煮法和剂型的选择;强调因人制宜;重视四时用药理论。

关键词: 《本草纲目》, 用毒, 警戒思想

Abstract: Objective To study the Compendium of Materia Medica from the perspective of pharmacovigilance, mine and reorganize pharmacovigilance thought of Chinese medicine and practical experiences in it. Methods By using traditional literature and data mining research methods, the contents of more than 1.9 million words in the Compendium of Materia Medica were filtered. We summarized the contents of use of drug toxicity in pharmacovigilance. Results There are a lot of records and methods in the Compendium of Materia Medica, which are about how to safely use the drugs and avoid adverse drug reactions in different links of drug use. Conclusion Use of drug toxicity in pharmacovigilance thought of the Compendium of Materia Medica is mainly embodied in the following aspects: paying attention to the compatibility and dietary taboos, promoting rational drug toxicity use, paying attention to the choice of dosage form and decocting method, emphasizing the factor of person and following the rule of drug for four seasons.

Key words: Compendium of Materia Medica, use of drug toxicity, pharmacovigilance thought

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