CAR-T的临床应用及潜在安全风险分析

摘要/Abstract

摘要： 目的介绍嵌合抗原受体（chimeric antigen receptor,CAR）T细胞疗法（CAR-T）的发展及临床应用情况,探讨疗效影响因素及潜在风险。方法检索国内外文献资料和相关数据库,分析影响CAR-T疗效和安全性的相关因素。结果 CAR-T为广大肿瘤患者提供了新的治疗选择,但其疗效受诸多因素影响,潜在安全性风险不容忽视。结论尽管目前还存在各种问题,但CAR-T的出现已经使肿瘤的免疫治疗进入一个全新阶段,其应用前景值得期待。

关键词: CAR-T, 细胞免疫技术, 脱靶效应, 细胞因子释放综合征

Abstract: Objective To introduce clinical application of chimeric antigen receptor T-cell therapy (CAR-T) and to explore the influencing factors of efficacy and potential risks. Methods Analyze information that affects the efficacy and safety of CAR-T therapy by retrieving literature and related databases at home and aboard. Results CAR-T provides a new treatment for cancer patients, but there are still many problems to be solved in terms of efficacy and safety. Conclusion CAR-T has shown great potential and will bring tumor immunotherapy to a new stage though many challenges ahead.

Key words: CAR-T, cell immunotherapy technology, on-target/off-tumor, cytokine release syndrome

中图分类号:

R994.11

许先兴, 杨静文. CAR-T的临床应用及潜在安全风险分析[J]. 中国药物警戒, 2018, 15(9): 555-559.

XU Xianxing, YANG Jingwen. Clinical Application and Potential Risk of CAR-T[J]. Chinese Journal of Pharmacovigilance, 2018, 15(9): 555-559.

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