生物力药理学研究进展

中国药物警戒 ›› 2018, Vol. 15 ›› Issue (8): 467-469.

• 生物力药理学研究专栏 • 上一篇下一篇

生物力药理学研究进展

张倩, 刘蕾, 游云^*, 廖福龙

中国中医科学院中药研究所,北京 100700

收稿日期:2018-10-11 修回日期:2018-10-11 出版日期:2018-08-20 发布日期:2018-10-11
通讯作者: 游云,女,研究员·博导,中药心脑血管药理学研究。E-mail:youyunrice@126.com
作者简介:张倩,女,在读硕士,中药心血管药理学研究。
基金资助:
国家自然科学基金（81274006）：基于生物力药理学的丹参药效机理研究; 中国中医科学院基本科研业务费自主选题项目（ZZ11-044）：基于Piezo1离子通道研究三七抗血小板聚集的生物力药理学机制

Development of Biomechanopharmacology

ZHANG Qian, LIU Lei, YOU Yun^*, LIAO Fulong

Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China

Received:2018-10-11 Revised:2018-10-11 Online:2018-08-20 Published:2018-10-11

摘要/Abstract

摘要： 本文从血流剪应力具有多靶点生物学效应阐释了生物力药理学的提出背景,并对近年来基于生物力药理学所开展的活血化瘀中药研究和抗血小板聚集药物研究的进展进行了总结分析。提出通过建立生物力药理学药物筛选模型,从机械力离子通道的角度发现抗血小板聚集的中药及化合物。

关键词: 生物力药理学, 血流剪应力, 抗血小板聚集

Abstract: This paper reveals formation of the borderline discipline of biomechanopharmacology from the multi-targeted biological effects of shear stress. It reviews the recent biomechanopharmacological studies of herbs with activating blood circulation and removing thrombosis effects, together with such studies of compounds with anti-platelets aggregation effects. We are looking forward to screening Chinese herbs through mechanical ion channel activator or inhibitor by means of biomechanopharmacology.

Key words: biomechanopharmacology, shear stress, anti-platelets aggregation

中图分类号:

R965

张倩, 刘蕾, 游云, 廖福龙. 生物力药理学研究进展[J]. 中国药物警戒, 2018, 15(8): 467-469.

ZHANG Qian, LIU Lei, YOU Yun, LIAO Fulong. Development of Biomechanopharmacology[J]. Chinese Journal of Pharmacovigilance, 2018, 15(8): 467-469.

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生物力药理学研究进展

Development of Biomechanopharmacology

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