中医药治疗前列腺癌方剂用药规律分析

中国药物警戒 ›› 2018, Vol. 15 ›› Issue (3): 158-162.

中医药治疗前列腺癌方剂用药规律分析

安婉丽, 杨鸿

中国中医科学院医学实验中心，北京 100700

收稿日期:2018-01-02 修回日期:2018-05-04 出版日期:2018-03-20 发布日期:2018-05-04
通讯作者: 杨鸿，女，博士，副研究员·硕导，代谢性疾病中医证候及中药复方及其配伍的分子机制研究。E-mail：yanghongchina@163.com
作者简介:安婉丽，女，在读硕士，中药组分复方的分子机制研究。
基金资助:
北京市中医药科技项目（Z161100001816003）：十病十药研发-治疗糖尿病肾病蛋白尿的中药-芪地糖肾颗粒新药临床前的药效学研究。

Analysis on Composition Principles of Traditional Chinese Medicine Prescriptions for Prostate Cancer

AN Wan-li, YANG Hong

Experimental Research Center, China Academy of Chinese Medical Science. Beijing 100700, China

Received:2018-01-02 Revised:2018-05-04 Online:2018-03-20 Published:2018-05-04

摘要/Abstract

摘要： 目的基于中医传承辅助系统软件，分析中医药治疗前列腺癌的用药模式及组方规律，预测新处方。方法通过中国全文期刊数据库（CNKI）、维普网仓储式在线出版平台、万方数据知识服务平台挖掘治疗前列腺癌有效的中医药方剂，对其运用中医传承辅助系统软件建立前列腺癌的方剂数据库，并分析其用药模式和组方规律，预测新处方。结果筛选治疗前列腺癌有效方剂289条，分析显示治疗前列腺癌的常用中药40味，补气类药物、滋补肝肾类药物使用频率最高，兼以清热解毒类药物、清热利湿类药物，活血化瘀类药物。常用药对组合模式14种，新方聚类核心组合6个及新方组合3个。推测新方功效分别为益气养阴，破血消；清热解毒，活血化瘀；滋补肝肾。结论分析显示的前列腺癌用药特点和组方规律为临床实践提供了参考。预测的新处方，其配伍组合符合临床思路，为指导临床用药及新药开发提供了初步依据。

关键词: 前列腺癌, 中医药, 中医传承辅助系统, 组方规律

Abstract: Objective To analyze the composing principles of herbs in the prescriptions for prostate cancer by using Traditional Chinese Medicine Inheritance System, and make predictions of new formulations according to the composing principles. Methods By retrieving Chinese medicine prescriptions about treatments of prostate cancer in China National Knowledge Infrastructure(CNKI), VIP net-Warehouse online publishing platform and Wan-fang Data-Knowledge service platform, the papers on prescriptions for prostate cancer were collected, and then Traditional Chinese Medicine Inheritance System was used to set up a database so as to analyze the composing principles of herbs in the prescriptions and predict new prescriptions. Results The 289 prescriptions in the database were screened to achieve 40 commonly used Traditional Chinese medicines, 14 commonly used drug combination modes,6 core combinations of new prescriptions and 3 new prescriptions. Analysis showed that the effects of herbs are mainly Invigorating Qi and Reinforcing Liver and Kidney, partially Clearing Heat Anti-toxicant, Clearing Heat and Dissolving Dampness and Promoting Blood Circulation for Removing Blood Stasis. The effects of new prescriptions obtained by cluster analysis were speculated to be Benefiting Qi for Nourishing Yin, Activating Blood and Resolving Accumulation; Heat Anti-toxicant, Promoting Blood Circulation for Removing Blood Stasis and Reinforcing Liver and Kidney. Conclusion Composing principles of herbs in the prescriptions for prostate cancer that we studied based on Traditional Chinese Medicine Inheritance System provides a reference for clinical practice. The predicted new prescriptions are in line with the clinical treatment considerations and provide a preliminary basis for clinical treatment and drug development

Key words: prostate cancer, traditional Chinese medicine, Traditional Chinese Medicine Inheritance System, prescription principles

中图分类号:

R969.3

安婉丽, 杨鸿. 中医药治疗前列腺癌方剂用药规律分析[J]. 中国药物警戒, 2018, 15(3): 158-162.

AN Wan-li, YANG Hong. Analysis on Composition Principles of Traditional Chinese Medicine Prescriptions for Prostate Cancer[J]. Chinese Journal of Pharmacovigilance, 2018, 15(3): 158-162.

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