中国药物警戒 ›› 2018, Vol. 15 ›› Issue (1): 52-56.

• 安全与合理用药 • 上一篇    下一篇

56例利妥昔单抗不良反应文献分析

诸慧1, 周丰2, 金剑1,*   

  1. 1 上海交通大学医学院附属第九人民医院药剂科,上海 200011;
    2 复旦大学药学院2014级,上海 201203;
  • 收稿日期:2018-02-12 修回日期:2018-02-12 出版日期:2018-01-20 发布日期:2018-02-12
  • 通讯作者: *金剑,男,硕士,副主任药师,临床药学。E-mail:ausword@126.com
  • 作者简介:诸慧,女,本科,主管药师,临床药学。

Literature Analysis of 56 Cases of Adverse Reactions Induced by Rituximab

ZHU Hui1, ZHOU Feng2, JIN Jian1,*   

  1. 1 Department of Pharmacy, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China;
    2 School of Pharmacy, Fudan University, Shanghai 201203, China;
  • Received:2018-02-12 Revised:2018-02-12 Online:2018-01-20 Published:2018-02-12

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摘要： 目的 讨论利妥昔单抗在临床使用中发生药品不良反应（ADR）的规律和特点,为临床用药提供参考。方法 检索2006年至2017年6月中国知网（CNKI）、万方数据库和Pubmed报道的56例使用利妥昔单抗所致ADR病例,对患者的一般情况、用药情况、ADR发生情况进行分析。结果 利妥昔单抗所致56例ADR病例中,男性患者34例（60.71%）,女性患者22例（39.29%）,60岁至69岁的患者构成比最多（33.93%）。ADR出现时间多发生于静脉滴注60 min以内及滴注完成后半年内。主要临床表现为呼吸系统损害和全身性损害。结论 临床应重视利妥昔单抗的ADR,加强治疗监测,坚持合理应用。

关键词: 利妥昔单抗, 美罗华, 药品不良反应

Abstract: Objective To discuss the regularity and characteristics of rituximab adverse reactions in clinical use, and to provide reference for clinical drug use. Methods A total of 56 ADR cases using rituximab were reported from 2006 to June 2017 in CNKI, Wanfang database and PUBMED. Then we analyzed the general condition, drug use and the incidence of ADR of patients. Results Of the 56 cases of ADR cases caused by rituximab, 34 cases (60.71%) were male patients, 22 cases (39.29%) were female patients, and the proportion of patients aged 60 to 69 was the largest (33.93%). The incidence of ADR mostly occurred in the intravenous infusion within 60 min and infusion within six months after the completion. The main clinical manifestations are respiratory damage and systemic damage. Conclusion We should pay attention to the ADR of rituximab clinically, and strengthen the monitoring of therapy, and adhere to the rational application.

Key words: rituximab, mabthera, adverse drug reaction

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