中国药物警戒 ›› 2017, Vol. 14 ›› Issue (2): 109-112.

• 安全性评价与合理用药 • 上一篇    下一篇

183例非典型抗精神病药品不良反应报告分析

张德伦1, 吕兰2, 姚鹏1, 蒋庆义1   

  1. 1 四川省南充精神卫生中心,四川 南充 637000;
    2 四川省南充市仪陇县人民医院,四川 仪陇 637600
  • 收稿日期:2017-03-10 修回日期:2017-03-10 出版日期:2017-02-20 发布日期:2017-03-10
  • 作者简介:张德伦,男,主管药师,临床药学。

Analysis of 183 Cases of Adverse Drug Reactions Induced by Atypical Antipsychotropic Drugs

ZHANG De-lun1, LU Lan2, YAO Peng1, JIANG Qing-yi1   

  1. 1 Mental Health Center of Nanchong City, Sichuan Nanchong 637000, China;
    2 People’s Hospital of Yilong County, Sichuan Yilong 637600, China;
  • Received:2017-03-10 Revised:2017-03-10 Online:2017-02-20 Published:2017-03-10

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摘要： 目的 了解非典型抗精神病药所致药品不良反应（ADR）发生的特点和规律,为临床合理用药提供参考。方法 采用病例回顾性研究方法,对某院2013-2016年收集到的183例非典型抗精神病药所致ADR的报告信息进行统计与分析。结果 183例ADR报告中,以21~40岁青壮年患者居多,共87例（占47.54%）;氯氮平和利培酮发生ADR的比例最高,分别占25.14%和23.50%;ADR累及系统-器官以神经系统损害最常见(占23.37%);严重不良反应如白/粒细胞减少、糖脂代谢异常、心率/心电图异常、肝功能异常等也较为常见（共占53.55%）。结论 非典型抗精神病药物可引起多种严重不良反应,应重视并加强对该类药物的合理应用和ADR监测,实施个体化用药,尽可能预防或减少ADR发生,确保患者用药安全。

关键词: 非典型抗精神病药, 药品不良反应, 分析, 合理用药

Abstract: Objective To learn the occurrence and characteristics of ADR caused by atypical antipsychotic drugs and provide information for rational drug use in clinical practice.Methods 183 ADR reports collected by our hospital from 2013 to 2016 were analyzed using retrospective study method.Results Among 183 cases of ADR reports, most patients were 21 to 40 years old, accounting for 87 cases (47.54%). ADR caused by clozapine and risperidone in the highest proportion accounted for 25.14% and 23.50%. The systems most commonly involved in ADR were nervous system (23.37% ).Serious adverse events such as leucopenia and glucolipid metabolic abnormalities and abnormal electrocardiogram and functional abnormality of the liver usually occurred (accounting for 53.55%).Conclusion Atypical antipsychotic drugs can cause a variety of serious adverse reactions. ADR monitoring and reporting of atypical antipsychotic drugs should be strengthened. The implementation of individualized medication, may avoid or reduce the occurrence of ADR and enhance safety of drug use in patients.

Key words: atypical antipsychotic drug, adverse drug reaction, analysis, rational drug use

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