中国药物警戒 ›› 2015, Vol. 12 ›› Issue (8): 503-505.

• 医院药事管理与合理用药 • 上一篇    下一篇

2例妊娠期原发性血小板增多症的合理用药分析

孙婉玲, 苏力, 周齐   

  1. 首都医科大学宣武医院,北京 100053
  • 收稿日期:2015-09-02 修回日期:2015-09-02 出版日期:2015-08-08 发布日期:2015-09-02
  • 通讯作者: 周齐,女,主任医师,高危妊娠与病理产科。E-mail: lk602@sina.com
  • 作者简介:孙婉玲,女,博士,副教授·硕导,血液病学。
  • 基金资助:
    国家自然科学基金资助项目（81000200）; 北京市卫生系统高层次卫生技术人才培养项目（2011-3-092）; 首都医科大学基础临床科研合作基金课题（15JL-L07）

Anaylysis of Rational Medication to Two Patients with Essential Thrombocythemia during Gestation Period

SUN Wan-ling, SU Li, ZHOU Qi   

  1. Xuanwu Hospital, Capital Medical University, Beijing 100053, China
  • Received:2015-09-02 Revised:2015-09-02 Online:2015-08-08 Published:2015-09-02

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摘要： 目的 总结分析2例原发性血小板增多症患者妊娠期及围产期的治疗过程,并进行相关文献复习。方法 评估2例妊娠原发性血小板增多症患者,根据患者危险度分层,在妊娠期及围产期分别给予个体化治疗。结果 1例高危患者妊娠期全程给予低分子肝素及干扰素α-2 b治疗,另1例低危患者妊娠期全程给予阿司匹林及干扰素α-2 b治疗;2例患者均安全娩出胎儿,产后12小时应用低分子肝素至围产期结束。结论 原发性血小板增多患者妊娠期及围产期极易出现各种并发症,需在血液科和产科医生的合作下,根据患者危险度分层给予全程个体化治疗、合理用药。

关键词: 原发性血小板增多, 妊娠期, 合理用药

Abstract: Objective To present the treatment of two essential thrombocythemia (ET) patients during gestation period and perinatal period, and analyze the rational medication. Methods Evaluated two ET patients, and individualized therapies were given during the gestation period and perinatal period according to the risk stratification. Results To the high risk patient, low molecular weight heparin (LMWH) and interferon α-2 b were applied during the whole gestation period; to the low risk patient, aspirin and interferon α-2 b were applied during the whole gestation period. Both patients delivered the fetus successfully, and LMWH was used from 12 hours to 6 weeks after delivery. Conclusion ET patients during gestation period and perinatal period are at high risk of complications. Evaluation of the prognosis, individualized treatment and rational drug use is required, by the cooperation of hematologists and obstetrists.

Key words: essential thrombocythemia, gestation period, rational drug use

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