中国药物警戒 ›› 2015, Vol. 12 ›› Issue (6): 332-334.

• 基础及临床研究 • 上一篇    下一篇

右美托咪定联合丙泊酚在胃镜检查术中的麻醉效果

刘龙娟   

  1. 陕西省铜川矿务局中心医院麻醉科，陕西 铜川 727000
  • 收稿日期:2015-02-14 出版日期:2015-06-08 发布日期:2015-07-27
  • 作者简介:刘龙娟，女，本科，主治医师，临床麻醉。

Anesthesia Effect of Dexmedetomidine Combined with Propofol in Gastroscopy

LIU Long-juan   

  1. Department of Anesthesiology, Central Hospital of Shanxi Tongchuan Mining, Shanxi Tongchuan, 727000, China
  • Received:2015-02-14 Online:2015-06-08 Published:2015-07-27

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摘要： 目的 探讨右美托咪定复合丙泊酚在胃镜检查术中的麻醉效果。方法 将78例接受静脉麻醉下无痛胃镜检查术的患者随机分为观察组与对照组各39例，对照组采用丙泊酚单药给药，观察组采用右美托咪定联合丙泊酚给药。结果 组内比较结果 显示，T1、T2、T3三个时间点，观察组的HR数值显著低于T0时数值（P <0.05），对照组的MAP与SpO2数值显著低于T0时数值（P <0.05）；组间比较结果 显示，T1、T2二个时间点，观察组的MAP与SpO2数值显著高于对照组（P <0.05），T1、T2、T3三个时间点，观察组的HR数值显著低于对照组（P <0.05）；观察组在丙泊酚总用量、麻醉诱导时间、苏醒时间及定向力恢复时间几个方面的数值均明显低于对照组，组间比较均有统计学意义（P <0.05）；观察组与对照组的不良反应总发生率分别为15.4%和35.9%，组间比较以观察组显著更低（P <0.05）。在T1、T2和T3麻醉深度，观察组均高于对照组（P <0.05）。结论 右美托咪定复合丙泊酚在胃镜检查术中的麻醉效果良好，值得推广使用。

关键词: 胃镜检查, 麻醉, 右美托咪定, 丙泊酚

Abstract: Objective To investigate the anesthesia effect of dexmedetomidine combined with propofol in gastroscopy. Methods 78 cases of patients were randomly divided into observation group and control group who received intravenous anesthesia painless gastroscopy. The control group received propofol,and the observation group received dexmedetomidine and propofol. Results Within groups, in T1, T2, T3 three time points, HR value of the observation group was significantly lower than the value at T0 (P <0.05), MAP and SpO2 values were significantly lower than T0 in control group (P <0.05). At T1, T2 two time points, MAP and SpO2 of the observation group was significantly higher (P <0.05). At T1, T2, T3 three time points, HR value of the observation group was significantly lower than in the control group (P <0.05). The observation group was significantly lower than the control group in total amount of propofol, anesthesia time, numerical aspects of recovery time and orientation recovery time (P <0.05). The overall incidence of adverse reactions was 15.4% and 35.9% in observation group and the control group, respectively. The observation group was significantly lower (P <0.05). In T1, T2 and T3 depth of anesthesia, the observation group was higher (P <0.05). Conclusion Dexmedetomidine combined with propofol showed a well anesthesia effect, could be used in gastroscopy.

Key words: gastroscopy, anesthesia, dexmedetomidine, propofol

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