中国药物警戒 ›› 2014, Vol. 11 ›› Issue (5): 304-305.

• 药械安全性研究 • 上一篇    下一篇

45例前列地尔的不良反应分析

黄茜, 张征2 刘丽宏 2*   

  1. 1北京市顺义区空港医院,北京 101318;
    2*首都医科大学附属北京朝阳医院药事部,北京 100020
  • 收稿日期:2016-02-03 修回日期:2016-02-03 出版日期:2014-05-08 发布日期:2016-03-02
  • 作者简介:黄茜,女,硕士,药师,临床药学。

Analysis of 45 Cases of Adverse Drug Reaction Induced by Alprostadil

HUANG Qian1, ZHANG Zheng2, LIU Li-hong2, *   

  1. 1Beijing Airport Hospital, Beijing 101318 China;
    2Department of Pharmacy, Beijing Chaoyang Hospital Affiliated to Capital University of Medical Sciences, Beijing 100020, China
  • Received:2016-02-03 Revised:2016-02-03 Online:2014-05-08 Published:2016-03-02

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摘要： 目的分析我院前列地尔所致不良反应的特点,为临床合理用药提供参考。方法收集2008~2012年度前列地尔所致不良反应报告,对患者性别、年龄、用药情况、不良反应表现、处理方法与结果等方面进行统计分析,归纳其不良反应特点。结果前列地尔不良反应报告45例,30岁以上居多,累及系统-器官主要为外周血管系统、皮肤和中枢神经系统,主要临床表现为静脉炎、皮疹、头晕、头痛,多数发生在用药0~3天后。结论应加强前列地尔不良反应的监测,及早预防,减少不良反应的发生。

关键词: 前列地尔, 不良反应

Abstract: ObjectiveTo analyze the adverse drug reaction(ADR) caused by alprostadil in our hospital and to provide reference to its rational use. MethodsThe cases of ADR by alprostadil reported in our hospital from 2008 to 2012 were collected. A statistical analysis was conducted based on gender, age, clinical manifestation, rescue strategies and prognosis of the ADR. ResultsFor 45 cases collected, the ages of patients were mostly over 30, the primary ADRs related organs or systems were peripheral vascular system, skin and central nervous system. The main clinical manifestations were phlebitis, rash, dizzy and headache, most appeared 0~3 days after dosing. ConclusionThe monitoring for adverse reactions of alprostadil should be strengthened. Early prevention can reduce the incidence of adverse reactions.

Key words: alprostadil, adverse drug reaction

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