中国药物警戒 ›› 2014, Vol. 11 ›› Issue (4): 225-228.

• 药械安全性研究 • 上一篇    下一篇

420例别嘌醇不良反应的文献分析

郑明节, 汤韧, 王春婷*   

  1. 国家食品药品监督管理总局药品评价中心,北京 100045
  • 收稿日期:2014-01-07 修回日期:2016-02-03 出版日期:2014-04-08 发布日期:2016-02-03
  • 作者简介:郑明节,女,主管药师,药品不良反应监测。

Literature Analysis of 420 Cases of Adverse Drug Reactions Induced by Allopurinol

ZHENG Ming-jie, TANG Ren, WANG Chun-ting*   

  1. Center for Drug Reevaluation, CFDA, Beijing 100045, China
  • Received:2014-01-07 Revised:2016-02-03 Online:2014-04-08 Published:2016-02-03

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摘要： 目的探讨别嘌醇致不良反应的一般规律特点,为临床合理用药提供参考。方法检索中国期刊全文数据库,对2013年之前国内公开发表有关别嘌醇致不良反应420例病例文献报道进行回顾性分析。结果老年男性患者发生率高,累及系统-器官主要为皮肤及其附件损害（42.33%）、全身性损害（22.77%）、肝胆系统损害（9.90%）,严重皮肤系统的损害以多形红斑型药疹、剥脱性皮炎超敏综合征为主。结论别嘌醇片安全使用丞待加强,临床应重视别嘌醇的不良反应,加强用药监测,确保安全使用。

关键词: 别嘌醇, 药品不良反应, 文献分析

Abstract: Objective To probe into the status,characterstics and influencing factors of ADR cases induced by allopurinol, for providing a reference for clinical treatment. Methods Data were collected from domestic published literatures from "China Journal Full-text Database" before 2013, and 420 case reports of adverse drug reactions induced by allopurinol were analyzed retrospectively. Results Older male patients appear to be with a high rate. Organs involved mainly are skin and its appendages(42.33%), systemic damage(22.77%), hepatobiliary system damage(9.90%). Severe damages to the skin are erythema multiforme system eruption , exfoliative dermatitis and hypersensitivity syndrome. Conclusion Allopurinol should be used reasonably, and the monitoring of clinical use should be strengthened to ensure the safety of medication.

Key words: allopurinol, adverse drug reactions, literature analysis

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