中国药物警戒 ›› 2014, Vol. 11 ›› Issue (3): 170-171.

• 药械安全性研究 • 上一篇    下一篇

54例奥硝唑氯化钠注射液不良反应分析

高艳云, 孙庆敏, 邱召娟*   

  1. 江苏省中医院,江苏 南京 210029
  • 收稿日期:2013-07-29 修回日期:2016-02-03 出版日期:2014-03-08 发布日期:2016-02-03
  • 作者简介:高艳云,女,中药师,药物合理应用。

Analysis of 54 Cases of Adverse Drug Reactions Induced by Ornidazole Sodium Chloride Injection

GAO Yan-Yun, SUN Qing-min, QIU Zhao-juan*   

  1. Traditional Chinese Medicine Hospital of Jiangsu Province, Jiangsu Nanjing 210029, China
  • Received:2013-07-29 Revised:2016-02-03 Online:2014-03-08 Published:2016-02-03

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摘要： 目的了解奥硝唑氯化钠注射液药品不良反应（ADR）发生的一般规律,促进临床合理用药。方法对我院2011年1月~2012年12月有关奥硝唑氯化钠注射液的54例不良反应报告从患者基本情况、不良反应发生时间、临床表现、用药情况等方面进行统计分析。结果54例ADR中女性多于男性,年龄主要集中在21~50岁之间。发生时间多为用药时,主要表现为皮肤过敏反应、消化系统反应、静脉炎等,存在3例危及生命的严重不良反应,21例存在合并用药情况。均无超剂量给药现象。结论使用奥硝唑期间应密切监测患者的用药反应,发现异常情况及时处置。多种药物序贯输注时,应科学安排药物输注顺序,单独给药,从而避免潜在性的危害。

关键词: 奥硝唑氯化钠注射液, 不良反应, 合理用药

Abstract: ObjectiveTo investigate the features of adverse drug reaction(ADR) induced by ornidazole sodium chloride injection in order to promote the safe drug use in clinic. MethodsThe ADR cases induced by ornidazole sodium chloride injection were searched between January 2011 and December 2012 in our hospital, and statistical analysis was made based on patients' basic characteristics, ADR time, clinical feature and drug use. ResultsThere were 54 ADR cases induced by ornidazole sodium chloride injection. The female cases were more than the males and patients' age was from 21 to 50 years old. The ADRs mostly occurred in the process of medication, mainly manifested as skin allergy, digestive reactions and phlebitis. There were 3 serious ADR cases, 21 cases had the combination of drug use, and no over-dose phenomenon. ConclusionThe patients treated with ornidazole sodium chloride injection should be closely monitored. The infusion should be scientifically arranged the sequence when multi-drugs are used so as to avoid potential hazards.

Key words: ornidazole sodium chloride injection, ADR, rational use of drugs

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