益母草临床应用和不良反应研究进展

中国药物警戒 ›› 2014, Vol. 11 ›› Issue (2): 74-76.

益母草临床应用和不良反应研究进展

冯群^{1, 2}, 赵红³, 孙蓉^{1*, *}

1山东省中医药研究院,山东济南,250014;
2天津中医药大学,天津 300073;
3中国人民解放军海军总医院,北京 100048

收稿日期:2013-01-31 修回日期:2016-02-03 出版日期:2014-02-08 发布日期:2016-02-03
通讯作者: 孙蓉,女,研究员,博士生导师,中药药理与毒理研究。E-mailsunrong107@163.com
作者简介:冯群,男,硕士,中药药理与毒理研究。

Research Progress of Clinical Applications and Adverse Reactions of Herba Leonuri

FENG Qun^{1, 2}, ZHAO Hong³, SUN Rong^{1, *}

1Shandong Academy of Chinese Medicine, Shandong Ji'nan 250014, China；
2Tianjin University of Traditional Chinese Medicine, Tianjin 300073, China；
3PLA Navy General Hospital, Beijing 100048,China

Received:2013-01-31 Revised:2016-02-03 Online:2014-02-08 Published:2016-02-03

摘要/Abstract

摘要： 目的明确益母草临床应用和不良反应,探讨药物功效与毒副作用相关性,为今后安全标准制订和进行功效物质基础下益母草的安全应用提供文献依据和研究思路。方法在梳理文献、古籍中对益母草的记载基础上,对近十几年来益母草国内外相关临床药理作用和不良反应报道进行整理、归纳与分析。结果益母草具有活血调经、利尿消肿的功效,是传统的妇科圣药。临床上也常用于治疗妇科常见疾病以及免疫系统、循环系统损伤等引起的疾病。大量关于益母草及含益母草的中成药的不良反应报道,在常规剂量或是过量服用益母草时易产生泌尿系统、生殖系统的损害,尤以肾脏、肝脏等器官的损伤为主。结论只有在益母草功效表达过程中,结合毒理学实验研究特点,才能提出切合益母草临床使用过程中与药品不良反应相关预警方案和早期诊疗措施,以确保其临床用药安全。

关键词: 益母草, 不良反应

Abstract: ObjectiveThe clinical applications and adverse reactions of Herba Leonuri were determined and the correlation of its efficacy and toxic and side effect were discussed. The literature evidence and research ideas were provided for making safety standards, and studying its safety based on its efficacious substance basis. MethodsAncient books, literature in past dynasties and references in the last decades at home and abroad about the efficacy and adverse reactions of Herba Leonuri were collated, analyzed and summarized. ResultsHerba Leonuri, which has the efficacy of promoting blood flowing, regulating menstruation, diuresis and detumescence, is a commonly used traditional Chinese gynecological medicine. It is always used to diseases of gynecology and diseases caused by immune system and circulatory system. A number of adverse reactions caused by Herba Leonuri and its preparations were reported. The adverse reactions of Herba Leonuri came down to urinary system, reproductive system, etc. And the most common organs damaged by Herba Leonuri were liver and kidney during conventional or excessive dose. ConclusionOnly under the process of efficacy-expression and conferring to the toxicological experiment of Herba Leonuri, can basement be provided for consummating safety standards and putting forward early-warning scheme of adverse reaction that can be referred in clinic. In this way Herba Leonuri can be ensured to be used safely.

Key words: Herba Leonuri, clinical application, adverse reaction

中图分类号:

R282

冯群, 赵红, 孙蓉. 益母草临床应用和不良反应研究进展[J]. 中国药物警戒, 2014, 11(2): 74-76.

FENG Qun, ZHAO Hong, SUN Rong. Research Progress of Clinical Applications and Adverse Reactions of Herba Leonuri[J]. Chinese Journal of Pharmacovigilance, 2014, 11(2): 74-76.

参考文献

[1] 国家药典委员会.中华人民共和国药典（一部）[M].北京：中国医药科技出版社,2010：272-273.
[2] 钟月平.益母草及其制剂在妇科的临床应用[J].湖南中医药大学学报,2010,30(10)：69-70.
[3] 李凤娟.浅析妇产科中的益母草应用[J].中医临床研究,2012,4(8)：53.
[4] 徐吉祥.消抗丸治疗AsAb免疫性不育症123例[J].陕西中医,2004,25(11)：999-1000.
[5] 杨丁友.益母草善治过敏性紫瘫[J].中医杂志,2003,14(11)：810-811.
[6] 薛孝明,姬存栓.益母化斑汤治疗小儿紫癜性肾炎20例[J].现代中医药,2006,26(1)：32-33.
[7] 邓琳,张莉,仲少敏,等.益母草和枸杞对UVB损伤角质形成细胞的保护作用[J].中国皮肤性病学杂志,2007,21(6)：324-326.
[8] 杨小清.益母草治疗荨麻疹疗效观察[J].中华现代中西医杂志,2003,1(2)：159.
[9] 刘圣君,任君旭,刘艳凯,等.益母草对失血性休克大鼠血流动力学的影响[J].中国临床康复,2006,10(23)：70-72.
[10] 郑国伟,陈少如.益母草片治疗心肌缺血的临床观察[J].中国中医药信息杂志,2000,7(2)：29.
[11] 梁艳丽,武平.自拟益气活血汤治疗冠心病40例[J].陕西中医,2000,21(9)：387.
[12] 许楚云,陈少如,何文贞,等.益母草注射液治疗急性脑梗死[J].中国新药与临床杂志,2002,21(5)：271-274.
[13] 戚甫国,郭德勇.益母草注射液治疗急性脑梗死的临床研究[J].中西医结合心脑血管病杂志,2003,1(2)：123-124.
[14] 曹勇,高胜营.益母草软肝汤治疗肝硬化腹水60例[J].中西医结合肝病杂志,2002,12(5)：303-304.
[15] 孙树良,郑杨.活血化瘀法治疗糖尿病肾病临床观察[J].辽宁中医学院学报,2006,8(2)：84-85.
[16] 葛邦雨.前列腺合剂治疗前列腺增生72例[J].陕西中医,2003,24(4)：320-321.
[17] 孙玉琦,马永刚,邢小燕,等.论中药不良反应的客观真实性[J].中国中药杂志,2006,31(16)：1381-1383.
[18] 贾祥生.益母草中毒致死1例[J].实用中医内科杂志,1989,3(3)：38.
[19] 刘建华.益母草中毒致血尿的辨证治疗例析[J].实用中医内科杂志,2002,16(3)：166.
[20] 林元秀.益母草加重痛经1例报告[J].实用中医药杂志,2000,16(10)：471.