阿德福韦酯治疗乙肝致低血磷性骨软化症的现状分析

中国药物警戒 ›› 2013, Vol. 10 ›› Issue (5): 294-298.

阿德福韦酯治疗乙肝致低血磷性骨软化症的现状分析

田月洁¹, 王金英^2*,谢彦军¹,路长飞¹,李振卿²,张翠芳³

1.山东省药品不良反应监测中心,山东济南250013；
2.东营市人民医院,山东东营257091；
3东营市药品不良反应监测中心,山东东营257091

收稿日期:2012-11-07 修回日期:2016-03-09 出版日期:2013-05-08 发布日期:2016-03-09
通讯作者: 王金英,女,主管药师,临床药学。 E-mail：dywjy9909@163.com
作者简介:田月洁,男,副主任药师,药品不良反应监测。

Current Situation Analysis on Hypophosphatemic Osteomalacia after Adefovir Dipivoxil Therapy for HepatitisB

TIAN Yue-jie¹ ,WANG Jin-ying^2*, XIE Yan-jun¹, LU Chang-fei¹, LI Zhen-qing² ,ZHANG Cui-fang³

1.Shandong Center for ADR Monitoring, Shandong Jinan 250013, China;
2.Dongying People's Hospital, Shandong Dongying 257091, China;
3.Dongying Center for ADR Monitoring, Shandong Dongying 257091, China

Received:2012-11-07 Revised:2016-03-09 Online:2013-05-08 Published:2016-03-09

摘要/Abstract

摘要： 对国内外关于阿德福韦酯低剂量给药导致低血磷性骨软化症的报道进行回顾性分析。调查表明,慢性乙型肝炎患者长期服用低剂量阿德福韦酯（每日10mg）可引起低磷性骨软化症,临床症状表现为进行性肌无力、骨痛,严重者造成骨折。国产药品说明书中无致骨软化症的警示,且临床难以确诊,应引起关注。对于阿德福韦酯引起骨软化症的发生频率、影响因素仍有待进一步研究。

关键词: 阿德福韦酯, 低血磷, 骨软化症

Abstract: Current situation of hypophosphatemic osteomalacia after adefovir dipivoxil therapy for hepatitis B with low dosage home and abroad was retrospectively analyzed. Investigations revealed hypophosphatemic osteomalacia might occur in chronic hepatitis B patients with long -term use of adefovir dipivoxil at dosage of 10mg per day. The clinical features were slowly progressive distal muscle weakness, bone pain or even fracture. For it's difficulty to accurately diagnose in clinic and there is no warnings in the domestic drug specifications, more attention should be paid to the adverse reaction. The frequency and influence factors should be further researched.

Key words: adfovir dipivoxil, hypophosphatemia, osteomalacia

中图分类号:

R978
R994.11

田月洁, 王金英,谢彦军,路长飞,李振卿,张翠芳 . 阿德福韦酯治疗乙肝致低血磷性骨软化症的现状分析[J]. 中国药物警戒, 2013, 10(5): 294-298.

TIAN Yue-jie ,WANG Jin-ying, XIE Yan-jun, LU Chang-fei, LI Zhen-qing ,ZHANG Cui-fang . Current Situation Analysis on Hypophosphatemic Osteomalacia after Adefovir Dipivoxil Therapy for HepatitisB [J]. Chinese Journal of Pharmacovigilance, 2013, 10(5): 294-298.

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