中国药物警戒 ›› 2013, Vol. 10 ›› Issue (3): 175-177.

• 药械安全性研究 • 上一篇    下一篇

21例骨瓜提取物致不良反应文献分析

易丹,罗晓波,陆向红   

  1. 株洲市一医院药剂科,湖南株洲 412000
  • 收稿日期:2011-08-06 修回日期:2016-03-09 出版日期:2013-03-08 发布日期:2016-03-09
  • 作者简介:易丹,女,硕士,主管药师,临床药学与不良反应监测。

Literature Analysis of 21 Cases of Adverse Drug Reactions Induced by Extraction of Bone-melon

YI Dan ,LUO Xiao-bo, LU Xiang-hong   

  1. The First Hospital of Zhuzhou; Hunan Zhuzhou 412000, China
  • Received:2011-08-06 Revised:2016-03-09 Online:2013-03-08 Published:2016-03-09

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摘要： 目的 探讨骨瓜提取物致不良反应的特点及相关因素,为临床合理用药提供参考。方法 检索1994 年～2012年国内医药期刊报道的骨瓜提取物所致不良反应案例,并进行统计、分析。结果 骨瓜提取物致不良反应在高年龄组发生率较高,多在用药过程中30 min 内发生。不良反应累及多个系统-器官,临床表现复杂多样,主要表现为变态反应,严重者可出现呼吸困难或过敏性休克。结论 临床医师、药师应重视骨瓜提取物的不良反应,坚持合理用药。

关键词: 骨瓜提取物, 药品不良反应, 文献, 分析

Abstract: Objective To explore the characteristics and related factors of adverse drug reactions (ADR) induced by extraction of bone-melon so as to provide references for rational clinical drug use. Methods ADR cases induced by extraction of bone -melon reported in domestic medical journals during 1994～2012 were collected and analyzed statistically. Restuls ADR induced by Extraction of Bone-melon often occurred in aged group. The onset of ADR was usually within 30min after injection. ADR could involve multiple organs and systems, and clinical manifestations were various, mainly allergic reactions. Severe allergic reactions could manifest dyspneic respiration and anaphylactic shock. Conclusion Clinical physicians and pharmacist should pay attention to the ADR induced by extraction of bone-melon and persist in rational drug use.

Key words: extraction of bone-melon, adverse drug reaction, literature, analysis

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