中国药物警戒 ›› 2013, Vol. 10 ›› Issue (3): 166-167.

• 药械安全性研究 • 上一篇    下一篇

44例5-HT3受体拮抗剂不良反应文献分析

吕新颜,梁茂本   

  1. 南京医科大学附属淮安第一医院,江苏淮安 223300
  • 收稿日期:2012-06-04 修回日期:2016-03-09 出版日期:2013-03-08 发布日期:2016-03-09
  • 作者简介:吕新颜,男,主管药师,临床药学。

Literature Analysis of 44 ADR Reports Induced by 5-HT3 Receptor Antagonist

LV Xin -yan ,LIANG Mao –ben   

  1. Huai'an First People's Hospital, Nanjing Medical University, Jiangsu Huai'an 223300, China
  • Received:2012-06-04 Revised:2016-03-09 Online:2013-03-08 Published:2016-03-09

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摘要： 目的 探讨5- 羟色胺3（5-HT3）受体拮抗剂致药品不良反应（ADR）的特点及相关因素,为临床合理用药提供参考。方法 利用“维普医药信息资源服务系统”、“万方数据医药信息系统”、“中华医学会全文期刊”、“中国医院数字图书馆”,以“昂丹司琼”、“格拉司琼”、“托烷司琼”、“阿扎司琼”、“雷莫司琼”、“5-HT3受体拮抗剂”等为题名进行全面搜索,对2000年1月~2011年12月国内公开报道的5-HT3受体拮抗剂所致的ADR44例进行统计分析。结果44例ADR 患者中男性20 例（45.45 %）,女性24 例（54.55%）,格拉司琼发生ADR 的例数最高30 例（68.18 %）,临床主要累及皮肤及附件、心血管系统、呼吸系统等。结论 临床应高度重视5-HT3受体拮抗剂的ADR,以确保安全用药。

关键词: 5-HT3, 拮抗剂, 不良反应

Abstract: Objective To explore the features and contributing factors of adverse drug reaction(ADR) induced by receptor antagonist and aims to provide reasonable suggestions in the clinical medication. Methods A statistical analysis was conducted on 44 ADR cases induced by 5-HT3 receptor antagonist, publicly reported during the years from January 2000 to December 2011. Terms like "Ondansetron Hydrochloride", "Granisetron Hydrochloride", "Tropisetron", "Azasetron hydrochloride", "Ramostetron Hydrochloride" and "5-HT3 receptor antagonist" were searched in major domestic journals and databases, such as VIP Medical Information Resources Service System, Wanfang Data Medical Information System, Journals of Chinese Medical Association, and Chinese Hospital Digital Database. Results of all the 44 ADR patients, 20 of them are male, accounting for 45.45% and 24 of them are female, comprising 54.55%. The ADR cases induced by Granisetron Hydrochloride reach up to 30(68.18%), and ADR was chiefly observed on skin, accessories, the cardiovascular system and the respiratory system. Conclusion High attention should be paid on the ADR related to 5-HT3 receptor antagonist in clinic in order to ensure the safe medication.

Key words: 5-HT3, antagonist, adverse drug reaction(ADR)

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