中国药物警戒 ›› 2013, Vol. 10 ›› Issue (2): 77-79.

• 辛夷毒效研究 • 上一篇    下一篇

辛夷酯素抗过敏作用机理探讨

钱晓路1,孙蓉2   

  1. 1.山东中医药大学,山东济南250355；
    2.山东省中医药研究院,山东济南250014
  • 收稿日期:2012-10-22 修回日期:2016-03-09 出版日期:2013-02-08 发布日期:2016-03-09
  • 通讯作者: 孙蓉,女,研究员,博士生导师,中药药理与毒理。E-mail：sunrong107@163.com
  • 作者简介:钱晓路,男,研究生,中药药理研究与评价。
  • 基金资助:
    国家重大新药创制重大专项课题,中药复方药理学研究与药效评价关键技术研究（2009ZX09502-015）；山东省科技攻关课题,辛夷抗过敏性鼻炎的实验与临床研究,（1997）年第 971226313号。

The Study on Antiallergenic Mechanisms of Effective Parts from Flos Magnoliae

QIAN Xiao -lu1, SUN Rong2   

  1. 1.Shandong University of Traditional Chinese Medicine,Shandong Jinan 250355, China;
    2.Shandong Research Academy of Traditional Chinese Medicine, Shandong Jinan 250014, China
  • Received:2012-10-22 Revised:2016-03-09 Online:2013-02-08 Published:2016-03-09

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摘要： 目的 探讨辛夷酯素抗过敏作用机理,为指导抗过敏药物的研发及指导临床用药提供参考及思路。方法 分别用形态法和荧光法观察辛夷酯素药物血清冻干粉对致敏大鼠腹腔肥大细胞（PMC）脱颗粒和组织胺释放的影响,研究辛夷酯素的抗过敏作用,探讨抗过敏机制。结果 给药15min、60min 后,制备的药物血清冻干粉对PMC 脱颗粒和组织胺释放有明显的抑制作用,且存在一定的时效关系。其抗过敏的机理可能与其稳定肥大细胞细胞膜,抑制其脱颗粒和释放过敏介质有关。结论 辛夷酯素对过敏症状有明显的抑制作用,其抗过敏机制与抑制PMC 释放过敏性介质组织胺有关。

关键词: 辛夷酯素, 抗过敏, 机理

Abstract: Objective The antiallergenic mechanisms of effective parts from Flos Magnoliae were studied, so as to provide references and research ideas for antiallergenic drugs and innovative drugs. Methods The effect of sensitized rat peritoneal mast cells(PMC) degranulation and the release of histamine about Flos Magnoliae effective parts of the freeze-dried powder of serum drug were observed through the patterns and fluorescence, the antiallergenic effects of Flos Magnoliaewas researched and the antiallergenic mechanisms was studied. Results The PMC degranulation and the release of histamine were significantly inhibited after given the preparation of freeze -dried powder of serum drug 15 and 60min, and there are some limitations relations. The antiallergenic mechanisms of Flos Magnoliae may be related to the mast cell membrane stability, inhibiting their degranulation and the release of allergic media. Conclusion The effective parts of Flos Magnoliae has an significant effect, and there are some relations about Flos Magnoliae effective antiallergenic parts and the release of allergic PMC medium-the histamine.

Key words: Flos Magnoliae, antiallergy, mechanisms

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