中国药物警戒 ›› 2012, Vol. 9 ›› Issue (6): 360-362.

• 药械安全性研究 • 上一篇    下一篇

主动集中监测法评价700例丹红注射液临床应用的安全性

康阿龙1，张娴1，黄黎明1，孙成荣2，马金强1   

  1. 1 解放军第四五一医院，陕西 西安 710054；
    2 解放军第三二三医院，陕西 西安 710054
  • 收稿日期:2011-02-22 出版日期:2012-06-10 发布日期:2015-08-10
  • 作者简介:康阿龙，男，副主任药师，中药制剂及医院药学研究。
  • 基金资助:
    国家科技支撑计划课题（2006038086056）; “重大新药创制”科技重大专项子课题（2009ZX09502-030）

Safety Evaluation of 700 cases of Danhong Injection in Its Clinical Application by Active Centralized Monitoring

KANG A-long1, ZHANG Xian1, HUANG Li-ming1, SUN Cheng-rong2, MAI Jin-qiang1   

  1. 1 PLA Hospital of No.451, Shanxi Xian 710054, China;
    2 PLA Hospital of No.323, Shanxi Xian 710054, China
  • Received:2011-02-22 Online:2012-06-10 Published:2015-08-10

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摘要： 目的对丹红注射剂临床应用的安全性进行再评价。方法采用集中主动监测法，监测我院2011年1月至10月中700例住院患者的用药情况、患者信息及发生的不良反应。结果共涉及8个科室的700个病例，16种疾病，不良反应3例，占0.43%（偶见）;老年人使用比例占73.71%;不合理用药105例，占15.00％。结论丹红注射剂临用应用不良反应发生率低，安全性较高;不合理用药给临床用药安全增加了风险，应加强中药注射剂临床合理使用监管。

关键词: 丹红注射液, 安全性, 主动集中监测

Abstract: Objective To evaluate the clinical safety of the Danhong injection． MethodsMedication and Patient data and ADR of 700 cases of Danhong Injection in our hospital were collected by active centralized minitoring during the period of January and October 2011． ResultsBased on the 700 inpatient cases which involved 8 departments and 16 rinds of diseases, whilst ADR occurred in 3 cases(0.43% of the total). 73.71% of the injection-takers were old patierits, 105 cases of the medication is unreasonable, accounting for 15.00％． Condusion A low incidence of ADR for the Danhong injection in its clinical application was found. Irrational drug use can increase safety risk. We should strengthen the supervision of clinical rational use of traditional Chinese medicine injections．

Key words: Danhong injection, safety, active centralized monitoring