中国药物警戒 ›› 2012, Vol. 9 ›› Issue (11): 689-690.

• 药械安全性研究 • 上一篇    下一篇

我院2006~2010年住院患者抗生素不良反应分析

彭庚1, 2, 华潞1, 刘玉清1*, 边文彦1, 李一石1   

  1. 1 中国医学科学院阜外心血管病医院,卫生部心血管药物临床研究重点实验室,北京 100037；
    2 河南省漯河市中心医院心内科,河南 漯河 462000
  • 收稿日期:2012-05-28 出版日期:2012-11-10 发布日期:2015-08-07
  • 通讯作者: 刘玉清,女,研究员,临床医学及药品不良反应监测研究。E-mail:yuqingliu9@163.com
  • 作者简介:彭庚,男,主治医师,心内科。
  • 基金资助:
    国家“十一五”科技支撑项目（2009ZX09501-32）

Analysis of Adverse Drug Reaction Induced by Antibiotic in Inpatients from 2006 to 2010

PENG Geng1, 2, HUA Lu1, LIU Yu-qing1*, BIAN WenYan1, LI Yi-shi1   

  1. 1 Fu Wai Hospital, CAMS, Key Laboratory of Clinical Trial Research in Cardiovascular Drugs, Ministry of Health, Beijing 100037, China;
    2 Luohe Central Hospital, Henan Luohe 46200, China
  • Received:2012-05-28 Online:2012-11-10 Published:2015-08-07

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摘要： 目的探讨抗生素致不良反应的发生情况,为临床规范、合理用药提供参考。方法对我院2006年2月至2010年12月住院患者上报的47例抗生素致不良反应病例,对患者的年龄、性别、不良反应史、用药途径、所用药物、不良反应临床表现等进行统计分析。结果抗生素致不良反应主要发生在41~60岁;β-内酰胺类抗生素致不良反应/事件最多;主要临床表现为皮肤过敏反应。结论医疗机构应重视抗生素引起的不良反应,加强抗生素的合理应用。

关键词: 抗生素, 药品不良反应

Abstract: ObjectiveTo investigate the adverse drug reaction(ADR) induced by antibiotic, and provide advice for the safety and rational use of drugs. MethodsTo conduct a statistical analysis based upon the information from 47 inpatients with ADR which were reported from February 2006 to December 2010, such as age, gender, history of adverse reactions with drugs, route of administration, used drug, clinical manifestations, et al. ResultsADR is likely to be reported in various ages section during inpatients, particularly those are 41~60 years old. The most adverse reactions were caused by beta-lactam antibiotics, and they mainly caused allergic skin reactions. ConclusionMedical institutions should pay attention to the antibiotic induced adverse reaction, and rational use of it.

Key words: antibiotic, adverse drug reaction(ADR)