中国药物警戒 ›› 2012, Vol. 9 ›› Issue (1): 51-53.

• 药品不良反应监测 • 上一篇    下一篇

我院228 例药品不良反应报告分析

刘玉清，王冬雪，边文彦，华潞，樊朝美，李一石*   

  1. 中国医学科学院阜外心血管病医院卫生部心血管病药物临床研究重点实验室，北京100037
  • 收稿日期:2011-02-14 出版日期:2012-01-10 发布日期:2015-08-10
  • 通讯作者: 李一石,女,博士生导师,主任医师,心血管临床药理研究。E-mail:liyishi@public3.bta.net.cn
  • 作者简介:刘玉清，女，研究员，临床医学，药品不良反应监测研究。
  • 基金资助:
    国家“十一五”科技重大专项（2009ZX09501-32）

Analysis of 228 Reports of Adverse Drug Reaction in Our Hospital

LIU Yu-qing, WANG Dong-xue, BIAN Wen-yan, HUA Lu, FAN Chao-mei, LI Yi-shi   

  1. Key Laboratory of Clinic Trial Research in Cardiovascular Drugs, Ministry of Health, Chinese Academy of Medical Science Peking Union Medical College Fu Wai Hospital, Beijing 100037,China
  • Received:2011-02-14 Online:2012-01-10 Published:2015-08-10

PDF (PC)

121

摘要： 目的研究和分析我院药品不良反应（ADR）发生的特点与规律，为临床合理用药提供参考。方法选用回顾性研究方法，对我院2006 年1 月~2010 年12 月收集和上报的228 例ADR 报告资料，分别按照患者性别、年龄、引发ADR 的药品种类、及临床表现等进行描述性统计分析。结果我院上报的228 例ADR，男性和女姓ADR 发生比例为1:1.38;共涉及106 种药品，包括多种心血管药品、抗生素、中成药等，其中降血压药、抗血栓药、调脂药及冠脉造影剂等心血管类药品ADR占较大比例;严重ADR的临床表现多样，其中造影剂所致过敏样反应较多，并有1例死亡。结论重视分析ADR报告资料，并将信息及时反馈给临床，这是做好ADR监测工作和减少不良反应发生的重要途径之一。

关键词: 药品不良反应, 分析, 监测

Abstract: Objective To study and analyze the characteristics and rules of the incidence of adverse drug reactions (ADR) reported in Fu Wai Hospital so as to provide references for rational drug use. Methods A total of 228 ADR reports collected from Jan. 2006 to Dec.2010 were described and analyzed retrospectively in respect of patients' gender,age, drug categories and clinical manifestation, etc. Results The male-female ratio among 228 ADR cases was 1:1.38 and 106 kinds of drugs were involved in, including various cardiovascular drugs, antibiotics, proprietary Chinese medicine, etc. ADR induced by cardiovascular drugs, such as antihypertension medication, antithrombotic, lipidlowering drugs and contrast medium used in coronarography occupied larger proportion. The clinic manifestation of serious ADR(SADR) was various. Among SADR cases, the number of cases who got allergic reaction induced by contrast agent was largest, one of which died. Conclusion It is important to analyze the ADR reports and feed back the related information to clinic, which is one of the important pathways to monitor ADR and reduce the ADR incidence.

Key words: adverse drug reaction, analysis, monitoring