疫苗和格林巴利综合征关联性研究进展

中国药物警戒 ›› 2011, Vol. 8 ›› Issue (9): 549-552.

疫苗和格林巴利综合征关联性研究进展

王亚丽, 侯永芳, 董铎, 刘翠丽, 王丹

国家食品药品监督管理局药品评价中心,北京 100045

收稿日期:2011-04-06 出版日期:2011-09-10 发布日期:2015-07-30
作者简介:王亚丽,女,博士,药品不良反应监测。
基金资助:
科技部课题资金资助项目（2009ZX10004-806）

Research Progress about Association between Vaccine and Guillain-Barr Syndrome

WANG Ya-li, HOU Yong-fang, DONG Duo, LIU Cui-li, WANG Dan

Center for Drug Reevaluation, SFDA, Beijing 100045, China

Received:2011-04-06 Online:2011-09-10 Published:2015-07-30

摘要/Abstract

摘要： 格林巴利综合征是一种神经系统自身免疫性疾病。迄今为止,病因仍不十分清楚,普遍认为微生物感染、疫苗接种、自身免疫状况、遗传、营养状况等因素与其发病有关。其发病率随地区、年龄、性别、人群、时期、国家等因素的变化而变化。许多疫苗和格林巴利综合征有联系,但一直没有因果关联性结论。本文通过检索近些年国内外发表的论文,介绍了疫苗和格林巴利综合征的研究进展,并提出了影响疫苗和格林巴利综合征关联性判定的因素。

关键词: 疫苗, 格林巴利综合征

Abstract: Guillain-Barré Syndrome(GBS) is an autoimmune disorder of nerves. Although the aetiology of GBS is not completely understood, it is broadly believed that lots of factors associated with it, such as infection, vaccination, immunization, genetic, nutrition, et al. The background rates of GBS change with region, age, gender, race, times and nations. There are many vaccines have temporal association with GBS. But causal association between them is not concluded. In this paper, the research progress about association between vaccination and GBS had been introduced through searching the papers published latest years. The factors which influence determining the association between vaccines and GBS are listed in the paper.

Key words: vaccine, Guillain-Barré, Syndrome

中图分类号:

R954

王亚丽, 侯永芳, 董铎, 刘翠丽, 王丹. 疫苗和格林巴利综合征关联性研究进展[J]. 中国药物警戒, 2011, 8(9): 549-552.

WANG Ya-li, HOU Yong-fang, DONG Duo, LIU Cui-li, WANG Dan. Research Progress about Association between Vaccine and Guillain-Barr Syndrome[J]. Chinese Journal of Pharmacovigilance, 2011, 8(9): 549-552.

参考文献

[1] 吴强强.格林巴利综合征相关研究近况[J].实用医药杂志, 2010, 27（7）：651-653.
[2] Haber P, Sejvar J, Mikaeloff Y, et al.Vaccines and Guillain-Barré Syndrome[J].Drug Saf, 2009, 32 (4): 309-323.
[3] Israeli E,Agmon-Levin N,Blank M,et al. Guillain Barré Syndrome-A Classical Autoimmune Disease Triggered by Infection or Vaccination[J].Clinic Rev Allerg Immunol,2010 Oct 5.[Epub ahead of print].
[4] 王殿华. 格林巴利综合征的病因及发病机制[J].中国社区医师, 2010, 38：4.
[5] Black S, Eskola J, Siegrist C-A, et al. Importance of background rates of disease in assessment of vaccine safety during mass immunisation with pandemic H1N1 influenza vaccines[J].Lancet, 2009, 374(9707): 2115-2122.
[6] Richard A, Hughes FRCP, Judith Charlton MS, et al. No Association Between Immunization and Guillain-Barré Syndrome in the United Kingdom, 1992 to 2000[J].Arch Intern Med.2006,166（12）:1301-1304.
[7] Landaverde JM, Danovaro-Holliday MC, Trumbo SP, et al. Guillain-Barré Syndrome in Children Aged <15 Years in Latin America and the Caribbean: Baseline Rates in the Context of the Influenza A (H1N1) Pandemic[J].J Infect Dis, 2010, 201(5):746-750.
[8] Guillain-Barré syndrome among recipients of Menactra meningo-coccal conjugate vaccine-United States, June-July 2005[J]. MMWR Morb Mortal Wkly Rep, 2005 Oct 14,54(40):1023-1025.
[9] Preliminary Results: Surveillance for Guillain-Barré Syndrome After Receipt of Influenza A(H1N1) 2009 Monovalent Vaccine-
United States, 2009-2010[J].MMWR Morb Mortal Wkly Rep, 2010 Jun 4,59(21):657-661.
[10] Liang XF, Li L, Liu DW, et al. safety of influenza A (H1N1) vaccine in postmarketing surveillance in china[J].N Engl J Med, 2011,364(7):638-647.
[11] Burwen DR, Ball R, Bryan WW, et al. Evaluation of Guillain-Barré Syndrome among recipients of influenza vaccine in 2000 and 2001[J]. Am J Prev Med, 2010,39(4):296-304.
[12] Kobayashi M, Takechi M, Kondo K, et al. Literature review on the association between inactivated influenza vaccines and the Guillain-Barré syndrome[J].Nippon Koshu Eisei Zasshi,2010,57(8):605-611.
[13] Update: Guillain-Barré syndrome among recipients of Menactra meningococcal conjugate vaccine-United States, June 2005-September 2006[J].MMWR Morb Mortal Wkly Rep,2006,55(41):1120-1124.
[14] Wals PD, Deceuninck G, Boucher RM, et al. Risk of Guillain-Barré Syndrome following Serogroup C Meningococcal Conjugate Vaccine in Quebec, Canada[J].Clin Infect Dis, 2008 ,46(8):75-77.
[15] Souayah N, Michas-Martin PA, Nasar A, et al. Guillain-Barré syndrome after Gardasil vaccination: data from Vaccine Adverse Event Reporting System 2006-2009[J].Vaccine, 2011,29(5):886-889.
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