中国药物警戒 ›› 2011, Vol. 8 ›› Issue (9): 515-517.

• 基础及临床研究 • 上一篇    下一篇

比索洛尔药品不良反应的临床观察

王一扬*, 王亦凡, 高振英   

  1. 河南省南阳市中心医院,河南 南阳 473009
  • 收稿日期:2010-07-26 出版日期:2011-09-10 发布日期:2015-07-30
  • 作者简介:王一扬,女,主管药师,临床药学。

A Clinical Study of the Adverse Drug Reactions of Bisoprolol

WANG Yi-yang, WANG Yi-fan, GAO Zhen-ying   

  1. Department of Pharmancy, Nanyang Center Hospital, Henan Nanyang 473009, China
  • Received:2010-07-26 Online:2011-09-10 Published:2015-07-30

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摘要： 目的 探讨比索洛尔片的药品不良反应。方法 随机选择216例原发性高血压病1-2级的患者,每日服比索洛尔片2.5mg,每周随访1次,如2周内血压未降至140/90mmHg以下,将剂量依次增至5mg、7.5mg、10mg,直至有效剂量或10mg剂量满8周。结果 61例出现药品不良反应,发生率28.24%。其中,日服2.5~5.0mg与日服7.5~10.0mg的药品不良反应发生率比较,两者有极显著差异（t =7.41,P<0.001）。因不良反应而停服比索洛尔治疗的26例,占12.04%。其中,日服2.5~5.0mg与日服7.5~10.0mg而停药所占比例比较,两者有极显著差别（t =4.78,P<0.001）。61例的药品不良反应中,发生在服用治疗剂量21日内的59例,占96.72%。因药物不良反应而停服比索洛尔治疗的26例中,发生在服用治疗剂量21日内的24例,占92.31%。结论 比索洛尔药品不良反应的发生率和因药品不良反应而停药的发生率均较高,且多发生在心血管系统,但多数均相对较轻、可耐受并可坚持用药治疗,或停药后较快恢复,说明比索洛尔应用较为安全。

关键词: 比索洛尔, 不良反应

Abstract: Objective To investigate the adverse drug reactions of Bisoprolol. Methods 216 cases of 1-2 level of essential hypertension patient, everyone of them takes the Bisoprolol tablet 2.5mg orally in the morning everyday. Patients were followed up once a week. If blood pressure has not been lowered to 140/90 mmHg following within 2 weeks, dosages are increased by take turns till 5 mg, 7.5mg, 10 mg, until effective dose or 10mg dosage full 8 weeks. Results 61 cases appeared adverse drug reactions, the incidence is 28.24%. for daily oral administration of 2.5-5.0mg, adverse drug reactions occurred in 16 cases, accounting for 11.59%. for daily oral administration of 7.5-10.0mg of 45 cases of adverse drug reaction occurred, accounting for 57.69%. There was a significant difference between the two groups(T=7.41,P<0.001). Stop Bisoprolol incidence of orally, and both have also the extremely remarkable different(T=4.78,P<0.001). Conclusion Bisoprolol incidence rate of adverse drug reactions and discontinuation treatment due to adverse drug reactions are higher. And it mostly occurs in the cardiovascular system, but most were relatively mild and tolerable, or may adhere to drug treatment, or rapid recovery after drug withdrawal, indicating Bisoprolol of more security.

Key words: Bisoprolol, adverse drug reaction(ADR)

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