中国药物警戒 ›› 2011, Vol. 8 ›› Issue (11): 687-689.

• 药品不良反应监测 • 上一篇    下一篇

262例儿童药物不良反应分析与评价

董懿珍, 张胜安, 刘欣宁, 胡晓红, 张伟   

  1. 开封市儿童医院 河南 开封 475000
  • 出版日期:2011-11-10 发布日期:2015-07-30
  • 作者简介:董懿珍,女,副主任药师,儿科临床药学。

The Analysis and Evaluation of 262 Cases of Adverse Drug Reactions in Children

DONG Yi-zhen, ZHANG Sheng-an, LIU Xin-ning, HU Xiao-hong, ZHANG Wei   

  1. Kaifeng Children's Hospital, Kaifeng Henan 475000, China
  • Online:2011-11-10 Published:2015-07-30

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摘要： 目的 了解儿童药物不良反应（ADRs）发生情况和危害,促进儿科临床合理用药。方法 对我院2006~2010年收集上报的262例药品不良反应资料进行回顾性分析和评价。结果 262例ADRs中,1个月至3岁婴幼儿发生ADRs最多,占总例数58.77%（154例）; 静脉给药ADRs发生率最高,占总例数97.3.%（255例）;在使用的药物中,抗生素ADRs发生率最高,占总例数55.34%（145例）,临床表现主要为变态反应,以皮肤及其附件损伤多见。结论 婴幼儿ADRs发生率较高,抗生素和静脉给药更易引起ADRs,应进一步加强儿童ADRs监测,避免和减少儿童ADRs发生。

关键词: 儿童, 药品不良反应, 合理用药

Abstract: Objective To realize the incidence and damage of the adverse drug reactions(ADRs) in children and promote rational use of drugs in pediatric clinical practice. Methods We collected 262 cases of ADRs in our hospital from 2006 to 2010, and retrospectively analyzed and evaluated them. Results In the 262 cases, most of the ADRs occurred in the infants from 1 months to 3 years, accounting for 58.77%(154 cases)of the total number. Introvenous injection was with the highest incidence of ADRs, 97.3%(255 cases) of the total number. Among the used drugs, antibiotics had the highest incidence of ADRs, 55.34%(145 cases) of the total number. Most of the clinical symptoms were allergic reactions, skin and accessories injury. Conclusion ADRs can easily happen in infants. Antibiotics or intravenous injection is prone to causing ADRs. We should further strengthen the monitoring of ADRs in children so as to reduce or avoid the occurence of it.

Key words: children, adverse drug reactions(ADRs), rational drug use

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