高分辨率CT在评价支气管哮喘患者的气道重塑中的作用

中国药物警戒 ›› 2010, Vol. 7 ›› Issue (5): 272-276.

高分辨率CT在评价支气管哮喘患者的气道重塑中的作用

张晓岩¹, 林江涛^1*, 李香凝², 刘翠丽³, 杨萌¹, 俞红霞¹

1卫生部中日友好医院呼吸内科,北京100029;
2卫生部中日友好医院放射科,北京 100029;
3国家食品药品监督管理局药品评价中心,北京 100045

收稿日期:2016-02-19 修回日期:2016-02-19 出版日期:2010-05-08 发布日期:2016-02-19
通讯作者: 林江涛,男,教授,主任医师,Email：jiangtao_l@263.net
作者简介:张晓岩,女,硕士,主治医师,支气管哮喘发病机制的研究。
基金资助:
北京市自然科学基金资助项目（项目编号：7063092）

The Evaluation of Airway Remodeling in Asthma Patients by HRCT

ZHANG Xiao-yan¹, LIN Jiang-tao^1,*, LI Xiang-ning², LIU Cui-li³, YANG Meng¹, YU Hong-xia¹

1Department of Respiratory Medicine, China-Japan Friendship Hospital, Beijing 100029, China;
2Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, China;
3Center for Drug Reevaluation, SFDA, Beijing 100045, China

Received:2016-02-19 Revised:2016-02-19 Online:2010-05-08 Published:2016-02-19

摘要/Abstract

摘要： 目的运用高分辨率CT（HRCT）观察支气管哮喘患者的气道重塑表现。方法将慢性持续期哮喘患者（37例）和健康人（20名）分列为哮喘组和对照组,运用HRCT观察所有受试者肺部影像学特征,运用PickerPQ6000分析软件测定气道壁厚度（T）、气道壁面积（WA）,采用气道壁厚度/气道外径（T/D）和气道壁面积占气道总面积百分比（WA%）做为标化指标。结果 WA轻度哮喘组（12.53±4.19）mm²和中重度哮喘组（14.68±5.96）mm²与健康对照组（9.32±3.78）mm²比较,差异有统计学意义（P <0.05）;轻度哮喘组和中重度哮喘组差异有统计学意义（P <0.05）。WA%值轻度哮喘组（70.51±7.04）％和中重度哮喘组（73.50±7.27）％,与对照组（64.80±5.45）％比较,差异有统计学意义（P <0.05）;轻度哮喘组与中重度哮喘组之间无统计学意义。T、T/D中重度哮喘组较轻度哮喘组和正常对照组差异有统计学意义（P <0.05）,但轻度哮喘组和正常对照组之间差异无统计学意义（P >0.05）。结论 HRCT可用于评价哮喘患者气道壁增厚和气道壁面积增加等气道重塑表现。

关键词: 气道重塑, 高分辨率CT

Abstract: Objective To explore the condition of airway remodeling in asthma patients by HRCT. Methods Everyone performed HRCT for the evaluation of the severity of asthma and airway remodeling. Quantitative assessment was used to analyze the thickness of airway wall(T, T/D) and airway w all area(WA, WA%). Results Comparison of Group1 (mild persistent asthma) and Group2(moderate and severe persistent) asthma with 20 control subjects revealed signif-icantly higher values of WA [(12.53±4.19)mm² for Group1, (14.68±5.96)mm² for Group2 and(9.32±3.78)mm² for controls, P<0.05], respectively and WA% of Group1 and Group2 were higher than control subjects,but no significant differences between each other.[(70.51±7.04)%, (73.50±7.27)% and (64.80±5.45)%, P<0.05]. T and T/D of Group2 were higher than Group1 and control subjects(P<0.05), but had no statistically significant differences between Group1 and control subjects(P>0.05). Conclusion HRCT is one of the Methods to evaluate the airway remodeling of asthma patients.

Key words: airway remodeling, high-resolution computed tomography(HRCT)

中图分类号:

R282

张晓岩, 林江涛, 李香凝, 刘翠丽, 杨萌, 俞红霞. 高分辨率CT在评价支气管哮喘患者的气道重塑中的作用[J]. 中国药物警戒, 2010, 7(5): 272-276.

ZHANG Xiao-yan, LIN Jiang-tao, LI Xiang-ning, LIU Cui-li, YANG Meng, YU Hong-xia. The Evaluation of Airway Remodeling in Asthma Patients by HRCT[J]. Chinese Journal of Pharmacovigilance, 2010, 7(5): 272-276.

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