中国药物警戒 ›› 2010, Vol. 7 ›› Issue (5): 262-264.

• 基础研究 • 上一篇    下一篇

中药细辛的遗传毒性实验研究

宋俊斋1, 李家亿1, 杨念1, 张林波2, 温得中1*   

  1. 1吉林大学白求恩医学院遗传系,吉林 长春130021;
    2吉林农业大学生命科学学院,吉林 长春 130118
  • 收稿日期:2016-02-19 修回日期:2016-02-19 出版日期:2010-05-08 发布日期:2016-02-19
  • 通讯作者: 温得中,男,副教授。E-mail：wendz@jlu.edu.cn
  • 作者简介:宋俊斋,女,在读硕士研究生,临床医学。

Experimental Study on Genetic Toxicity of Asarum Heterotropoides Fr.Schmidt

SONG Jun-zhai1, LI Ja-yi1, YANG Nian1, ZHANG Lin-bo2, WEN De-zhong1,*   

  1. 1Norman Bethune College of Medicine Jilin University, Jilin Changchun 130021, China;
    2College of Life Sciences Jilin Agricultural University, Jilin Changchun 130118, China
  • Received:2016-02-19 Revised:2016-02-19 Online:2010-05-08 Published:2016-02-19

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摘要： 目的 研究中药细辛的遗传毒性,为临床用药提供理论依据。方法 应用小鼠骨髓嗜多染红细胞微核实验和精子畸形实验,观察细辛水煎液在小鼠体内对雄性体细胞和生殖细胞遗传物质的损伤,通过微核率和畸形率评价细辛对雄性小鼠的遗传毒性作用。结果 细辛水煎液能明显诱发小鼠骨髓嗜多染红细胞微核和小鼠精子畸形,具有致突变作用。结论 中药细辛作为临床常用的中草药,临床应用时需考虑其遗传毒性。

关键词: 细辛, 环磷酰胺, 精子畸形, 微核

Abstract: Objective To study the genetic toxicity of Asarum heterotropoides Fr.Schmidt. Methods Observation whether the Decoction of Asarum heterotropoides Fr.Schmidt.Var. mandshuricum Kitag. will induce genetic material injury in male mice' somatic and germ cells or not by mouse polychromatic erythrocytes micronucleus test and mouse sperm abnormality test, indicated the genetic toxicity of Asarum heterotropoides Fr.Schmidt. by micronucleus rate and the malformation rate and deformity constituent ratio. Results Asarum heterotropoides Fr.Schmidt. could significantly induce mouse polychromatic ery-throcytes micronuclei and sperm abnormalities, it has mutagenic effect. Conclusion Asarum heterotropoides Fr.Schmidt. as a clinical efficacy of commonly used Chinese herbal medicine has a variety of genetic toxicity, clinical applications need to consider their genetic toxicity.

Key words: Asarum heterotropoides Fr.Schmidt, cyclophosphamide, sperm abnormality, micronuclei

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